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dc.contributor.authorA. Youngson, Neil
dc.contributor.authorEpp, Trevor
dc.contributor.authorRoberts, Amity
dc.contributor.authorDaxinger, Lucia
dc.contributor.authorAshe, Alyson
dc.contributor.authorHuang, Edward
dc.contributor.authorL. Lester, Krystal
dc.contributor.authorK. Harten, Sarah
dc.contributor.authorF. Kay, Graham
dc.contributor.authorCox, Timothy
dc.contributor.authorM. Matthews, Jacqueline
dc.contributor.authorChong, Suyinn
dc.contributor.authorWhitelaw, Emma
dc.date.accessioned2017-05-03T11:12:38Z
dc.date.available2017-05-03T11:12:38Z
dc.date.issued2013
dc.date.modified2013-11-11T22:47:03Z
dc.identifier.issn09388990
dc.identifier.doi10.1007/s00335-013-9451-5
dc.identifier.urihttp://hdl.handle.net/10072/54231
dc.description.abstractObservations of inherited phenotypes that cannot be explained solely through genetic inheritance are increasing. Evidence points to transmission of non-DNA molecules in the gamete as mediators of the phenotypes. However, in most cases it is unclear what the molecules are, with DNA methylation, chromatin proteins, and small RNAs being the most prominent candidates. From a screen to generate novel mouse mutants of genes involved in epigenetic reprogramming, we produced a DNA methyltransferase 3b allele that is missing exon 13. Mice that are homozygous for the mutant allele have smaller stature and reduced viability, with particularly high levels of female post-natal death. Reduced DNA methylation was also detected at telocentric repeats and the X-linked Hprt gene. However, none of the abnormal phenotypes or DNA methylation changes worsened with multiple generations of homozygous mutant inbreeding. This suggests that in our model the abnormalities are reset each generation and the processes of transgenerational epigenetic reprogramming are effective in preventing their inheritance.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom206
dc.relation.ispartofpageto217
dc.relation.ispartofissue5-6
dc.relation.ispartofjournalMammalian Genome
dc.relation.ispartofvolume24
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode3105
dc.titleNo evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorRoberts, Amity R.


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