Show simple item record

dc.contributor.authorKarimabad, Mojgan Noroozi
dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorHakimizadeh, Elham
dc.contributor.authorDaredori, Hassan Yousefi
dc.contributor.authorNazari, Mahmood
dc.contributor.authorHassanshahi, Gholamhossein
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-05-03T11:12:36Z
dc.date.available2017-05-03T11:12:36Z
dc.date.issued2013
dc.date.modified2013-11-19T03:55:26Z
dc.identifier.issn0360-3997
dc.identifier.doi10.1007/s10753-012-9517-7
dc.identifier.urihttp://hdl.handle.net/10072/54321
dc.description.abstractImmune responses are the main causes of immune system-related diseases such as hypersensitivities and autoimmunity. It has also been established that cytokines play key roles in the regulation of immune responses which have been shown to be important in the pathogenesis of the diseases. IL-10, the main anti-inflammatory cytokine, is produced by several immune cells such as T regulatory and Th2 lymphocytes, activated macrophages, B regulatory lymphocytes as well as other cell types. It plays a key role in the regulation of immune responses after microbe elimination (homeostasis) and against self-antigens to prevent hypersensitivity and autoimmune diseases, respectively. Studies showed that a single nucleotide polymorphism (SNP) at the -592 position of IL- 10 is associated with its regulation of expression. This review addresses the recent information regarding the association of the polymorphism at position -592 of IL-10 with immune-related diseases including type 2 diabetes with and without nephropathy, multiple sclerosis, and asthma with an emphasize on Iranian patients.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom35
dc.relation.ispartofpageto41
dc.relation.ispartofissue1
dc.relation.ispartofjournalInflammation
dc.relation.ispartofvolume36
dc.rights.retentionY
dc.subject.fieldofresearchAutoimmunity
dc.subject.fieldofresearchImmunogenetics (incl. Genetic Immunology)
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110703
dc.subject.fieldofresearchcode110706
dc.subject.fieldofresearchcode1107
dc.titleIs the IL-10 Promoter Polymorphism at Position -592 Associated with Immune System-Related Diseases?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record