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dc.contributor.authorAhmadabadi, Behzad Nasiri
dc.contributor.authorHassanshahi, Gholamhossein
dc.contributor.authorKhoramdelazad, Hossein
dc.contributor.authorMirzaei, Vahid
dc.contributor.authorSajadi, Seyed Mohammad Ali
dc.contributor.authorHajghani, Masomeh
dc.contributor.authorKhodadadi, Hassan
dc.contributor.authorPourali, Reza
dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-05-03T11:12:37Z
dc.date.available2017-05-03T11:12:37Z
dc.date.issued2013
dc.date.modified2013-11-19T04:35:49Z
dc.identifier.issn0360-3997
dc.identifier.doi10.1007/s10753-012-9528-4
dc.identifier.urihttp://hdl.handle.net/10072/54360
dc.description.abstractStudies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8+ T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8+ T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5+/CD8+ T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom136
dc.relation.ispartofpageto140
dc.relation.ispartofissue1
dc.relation.ispartofjournalInflammation
dc.relation.ispartofvolume36
dc.rights.retentionY
dc.subject.fieldofresearchInfectious diseases
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode320211
dc.subject.fieldofresearchcode3204
dc.titleDownregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


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