dc.contributor.author | Ahmadabadi, Behzad Nasiri | |
dc.contributor.author | Hassanshahi, Gholamhossein | |
dc.contributor.author | Khoramdelazad, Hossein | |
dc.contributor.author | Mirzaei, Vahid | |
dc.contributor.author | Sajadi, Seyed Mohammad Ali | |
dc.contributor.author | Hajghani, Masomeh | |
dc.contributor.author | Khodadadi, Hassan | |
dc.contributor.author | Pourali, Reza | |
dc.contributor.author | Arababadi, Mohammad Kazemi | |
dc.contributor.author | Kennedy, Derek | |
dc.date.accessioned | 2017-05-03T11:12:37Z | |
dc.date.available | 2017-05-03T11:12:37Z | |
dc.date.issued | 2013 | |
dc.date.modified | 2013-11-19T04:35:49Z | |
dc.identifier.issn | 0360-3997 | |
dc.identifier.doi | 10.1007/s10753-012-9528-4 | |
dc.identifier.uri | http://hdl.handle.net/10072/54360 | |
dc.description.abstract | Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8+ T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8+ T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5+/CD8+ T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 136 | |
dc.relation.ispartofpageto | 140 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | Inflammation | |
dc.relation.ispartofvolume | 36 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Infectious diseases | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearchcode | 320211 | |
dc.subject.fieldofresearchcode | 3204 | |
dc.title | Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2013 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Kennedy, Derek D. | |