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dc.contributor.authorHugh, EJ
dc.contributor.authorMitchell, Geoffrey K
dc.contributor.authorNikles, Jane
dc.contributor.authorCarmont, Sue-Ann
dc.contributor.authorSchluter, Philip J
dc.contributor.authorCurrow, David C
dc.contributor.authorVora, Rohan
dc.contributor.authorYelland, Michael J
dc.contributor.authorAgar, Meera
dc.contributor.authorGood, Phillip D
dc.contributor.authorHardy, Janet R
dc.date.accessioned2017-08-09T22:28:54Z
dc.date.available2017-08-09T22:28:54Z
dc.date.issued2013
dc.date.modified2014-06-11T03:10:31Z
dc.identifier.issn1472-684X
dc.identifier.doi10.1186/1472-684X-12-17
dc.identifier.urihttp://hdl.handle.net/10072/54727
dc.description.abstractBackground: It is estimated that 29% of deaths in Australia are caused by malignant disease each year and can be expected to increase with population ageing. In advanced cancer, the prevalence of fatigue is high at 70–90%, and can be related to the disease and/or the treatment. The negative impact of fatigue on function (physical, mental, social and spiritual) and quality of life is substantial for many palliative patients as well as their families/carers. Method/design: This paper describes the design of single patient trials (n-of-1 s or SPTs) of a psychostimulant, methylphenidate hydrochloride (MPH) (5 mg bd), compared to placebo as a treatment for fatigue, with a population estimate of the benefit by the aggregation of multiple SPTs. Forty patients who have advanced cancer will be enrolled through specialist palliative care services in Australia. Patients will complete up to 3 cycles of treatment. Each cycle is 6 days long and has 3 days treatment and 3 days placebo. The order of treatment and placebo is randomly allocated for each cycle. The primary outcome is a reduction in fatigue severity as measured by the Functional Assessment of Cancer Therapy-fatigue subscale (FACIT-F). Secondary outcomes include adverse events, quality of life, additional fatigue assessments, depression and Australian Karnovsky Performance Scale. Discussion: This study will provide high-level evidence using a novel methodological approach about the effectiveness of psychostimulants for cancer-related fatigue. If effective, the findings will guide clinical practice in reducing this prevalent condition to improve function and quality of life.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent268130 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom17-1
dc.relation.ispartofpageto17-6
dc.relation.ispartofjournalBMC Palliative Care
dc.relation.ispartofvolume12
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1110
dc.subject.fieldofresearchcode1117
dc.titleUsing aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocol
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 17.
gro.rights.copyright© 2013 Senior et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorYelland, Michael


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