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  • Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology

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    Author(s)
    Nam-Trung, Nguyen
    Shaegh, Seyed Ali Mousavi
    Kashaninejad, Navid
    Dinh-Tuan, Phan
    Griffith University Author(s)
    Nguyen, Nam-Trung
    Kashaninejad, Navid
    Year published
    2013
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    Abstract
    Lab-on-a-chip technology is an emerging field evolving from the recent advances of micro- and nanotechnologies. The technology allows the integration of various components into a single microdevice. Microfluidics, the science and engineering of fluid flow in microscale, is the enabling underlying concept for lab-on-a-chip technology. The present paper reviews the design, fabrication and characterization of drug delivery systems based on this amazing technology. The systems are categorized and discussed according to the scales at which the drug is administered. Starting with the fundamentals on scaling laws of mass transfer ...
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    Lab-on-a-chip technology is an emerging field evolving from the recent advances of micro- and nanotechnologies. The technology allows the integration of various components into a single microdevice. Microfluidics, the science and engineering of fluid flow in microscale, is the enabling underlying concept for lab-on-a-chip technology. The present paper reviews the design, fabrication and characterization of drug delivery systems based on this amazing technology. The systems are categorized and discussed according to the scales at which the drug is administered. Starting with the fundamentals on scaling laws of mass transfer and basic fabrication techniques, the paper reviews and discusses drug delivery devices for cellular, tissue and organism levels. At the cellular level, a concentration gradient generator integrated with a cell culture platform is the main drug delivery scheme of interest. At the tissue level, the synthesis of smart particles as drug carriers using lab-on-a-chip technology is the main focus of recent developments. At the organism level, microneedles and implantable devices with fluid-handling components are the main drug delivery systems. For drug delivery to a small organism that can fit into a microchip, devices similar to those of cellular level can be used.
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    Journal Title
    Advanced Drug Delivery Reviews
    Volume
    65
    Issue
    11-12
    DOI
    https://doi.org/10.1016/j.addr.2013.05.008
    Copyright Statement
    © 2013 Elsevier Inc. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Microelectromechanical systems (MEMS)
    Pharmacology and pharmaceutical sciences
    Basic pharmacology
    Publication URI
    http://hdl.handle.net/10072/54801
    Collection
    • Journal articles

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