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dc.contributor.authorHuang, Yuli
dc.contributor.authorNam-Trung, Nguyen
dc.contributor.editorFerrari M.
dc.date.accessioned2017-05-03T16:14:45Z
dc.date.available2017-05-03T16:14:45Z
dc.date.issued2013
dc.identifier.issn1387-2176
dc.identifier.doi10.1007/s10544-013-9796-2
dc.identifier.urihttp://hdl.handle.net/10072/54873
dc.description.abstractThis paper reports the design, fabrication and characterization of a cell stretching device based on the side stretching approach. Numerical simulation using finite element method provides a guideline for optimizing the geometry and maximizing the output strain of the stretched membrane. An unique PDMS-based micro fabrication process was developed for obtaining high parallelization, well controlled membrane thickness and an ultra-thin bottom layer that is crucial for the use with confocal microscopes. The stretching experiments are fully automated with both device actuation and image acquisition. A programmable pneumatic control system was built for simultaneous driving of 24 stretching arrays. The actuation signals are synchronized with the image acquisition system to obtain time-lapse recording of cells grown on the stretched membrane. Experimental results verified the characteristics predicted by the simulation. A platform with 15 stretching units was integrated on a standard 24 mm נ50 mm glass slide. Each unit can achieve a maximum strain of more than 60 %. The platform was tested for cell growth under cyclic stretching. The preliminary results show that the device is compatible with all standard microscopes.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1365993 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1043
dc.relation.ispartofpageto1054
dc.relation.ispartofissue6
dc.relation.ispartofjournalBiomedical Microdevices
dc.relation.ispartofvolume15
dc.rights.retentionY
dc.subject.fieldofresearchSignal transduction
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchMaterials engineering
dc.subject.fieldofresearchMicroelectromechanical systems (MEMS)
dc.subject.fieldofresearchcode310111
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode4016
dc.subject.fieldofresearchcode401705
dc.titleA polymeric cell stretching device for real-time imaging with optical microscopy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2013 Springer. This is an electronic version of an article published in Biomedical Microdevices, Vol. 15(6), pp. 1043-1054, 2013. Biomedical Microdevices is available online at: http://link.springer.com/ with the open URL of your article.
gro.date.issued2014-12-10T21:43:43Z
gro.hasfulltextFull Text
gro.griffith.authorNguyen, Nam-Trung


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