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  • Immunoediting of cancers may lead to epithelial to mesenchymal transition

    Author(s)
    Knutson, Keith
    Lu, Hailing
    Stone, Brad
    M. Reiman, Jennifer
    D. Behrens, Marshall
    M. Prosperi, Christine
    A. Gad, Ekram
    Smorlesi, Arianna
    L. Disis, Mary
    Griffith University Author(s)
    Reiman, Jennifer M.
    Year published
    2006
    Metadata
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    Abstract
    Tumors evade both natural and pharmacologically induced (e.g., vaccines) immunity by a variety of mechanisms, including induction of tolerance and immunoediting. Immunoediting results in reshaping the immunogenicity of the tumor, which can be accompanied by loss of Ag expression and MHC molecules. In this study, we evaluated immunoediting in the neu-transgenic mouse model of breast cancer. A tumor cell line that retained expression of rat neu was generated from a spontaneous tumor of the neu-transgenic mouse and, when injected into the non-transgenic parental FVB/N mouse, resulted in the development of a strong immune response, ...
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    Tumors evade both natural and pharmacologically induced (e.g., vaccines) immunity by a variety of mechanisms, including induction of tolerance and immunoediting. Immunoediting results in reshaping the immunogenicity of the tumor, which can be accompanied by loss of Ag expression and MHC molecules. In this study, we evaluated immunoediting in the neu-transgenic mouse model of breast cancer. A tumor cell line that retained expression of rat neu was generated from a spontaneous tumor of the neu-transgenic mouse and, when injected into the non-transgenic parental FVB/N mouse, resulted in the development of a strong immune response, initial rejection, and ultimately the emergence of neu Ag-loss variants. Morphologic and microarray data revealed that the immunoedited tumor cells underwent epithelial to mesenchymal transition accompanied by an up-regulation of invasion factors and increased invasiveness characteristic of mesenchymal tumor cells. These results suggest that immunoediting of tumor results in cellular reprogramming may be accompanied by alterations in tumor characteristics including increased invasive potential. Understanding the mechanisms by which tumors are immunoedited will likely lead to a better understanding of how tumors evade immune detection.
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    Journal Title
    Journal of Immunology
    Volume
    177
    Issue
    3
    Publisher URI
    http://www.jimmunol.org/content/177/3/1526.abstract
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Tumour Immunology
    Immunology
    Publication URI
    http://hdl.handle.net/10072/54897
    Collection
    • Journal articles

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