dc.contributor.author | P. R. Sutherland, Andrew | |
dc.contributor.author | Ng, Lai Guan | |
dc.contributor.author | A. Fletcher, Carrie | |
dc.contributor.author | Shum, Bennett | |
dc.contributor.author | A. Newton, Rebecca | |
dc.contributor.author | T. Grey, Shane | |
dc.contributor.author | S. Rolph, Michael | |
dc.contributor.author | Mackay, Fabienne | |
dc.contributor.author | Mackay, Charles R. | |
dc.date.accessioned | 2017-05-03T16:02:15Z | |
dc.date.available | 2017-05-03T16:02:15Z | |
dc.date.issued | 2005 | |
dc.date.modified | 2013-12-12T03:27:23Z | |
dc.identifier.issn | 1550-6606 | |
dc.identifier.uri | http://hdl.handle.net/10072/54899 | |
dc.description.abstract | B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B cell maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in the development of autoimmune disorders. BAFF also affects T cell function through binding to one of the BAFF receptors, BAFF-R. Using BAFF Tg mice, we examined a typical Th1-mediated response, the cutaneous delayed-type hypersensitivity reaction, and found a much greater degree of paw swelling and inflammation than in control mice. Importantly, delayed-type hypersensitivity scores correlated directly with BAFF levels in serum. Conversely, in a Th2-mediated model of allergic airway inflammation, BAFF Tg mice were largely protected and showed markedly reduced Ag-specific T cell proliferation and eosinophil infiltration associated with the airways. Thus, local and/or systemically distributed BAFF affects Th1 and Th2 responses and impacts on the course of some T cell-mediated inflammatory reactions. Our results are consistent with the idea that BAFF augments T cell as well as B cell responses, particularly Th1-type responses. Results in BAFF Tg mice may reflect the situation in certain autoimmune patients or virally infected individuals, because BAFF levels in blood are comparable. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Association of Immunologists | |
dc.publisher.place | United States | |
dc.publisher.uri | http://www.jimmunol.org/content/174/9/5537.abstract | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 5537 | |
dc.relation.ispartofpageto | 5544 | |
dc.relation.ispartofissue | 9 | |
dc.relation.ispartofjournal | Journal of Immunology | |
dc.relation.ispartofvolume | 174 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Cellular Immunology | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearchcode | 110704 | |
dc.subject.fieldofresearchcode | 1107 | |
dc.title | BAFF Augments Certain Th1-Associated Inflammatory Responses | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information. | |
gro.date.issued | 2005 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Rolph, Michael S. | |