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dc.contributor.authorP. R. Sutherland, Andrew
dc.contributor.authorNg, Lai Guan
dc.contributor.authorA. Fletcher, Carrie
dc.contributor.authorShum, Bennett
dc.contributor.authorA. Newton, Rebecca
dc.contributor.authorT. Grey, Shane
dc.contributor.authorS. Rolph, Michael
dc.contributor.authorMackay, Fabienne
dc.contributor.authorMackay, Charles R.
dc.date.accessioned2017-05-03T16:02:15Z
dc.date.available2017-05-03T16:02:15Z
dc.date.issued2005
dc.date.modified2013-12-12T03:27:23Z
dc.identifier.issn1550-6606
dc.identifier.urihttp://hdl.handle.net/10072/54899
dc.description.abstractB cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B cell maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in the development of autoimmune disorders. BAFF also affects T cell function through binding to one of the BAFF receptors, BAFF-R. Using BAFF Tg mice, we examined a typical Th1-mediated response, the cutaneous delayed-type hypersensitivity reaction, and found a much greater degree of paw swelling and inflammation than in control mice. Importantly, delayed-type hypersensitivity scores correlated directly with BAFF levels in serum. Conversely, in a Th2-mediated model of allergic airway inflammation, BAFF Tg mice were largely protected and showed markedly reduced Ag-specific T cell proliferation and eosinophil infiltration associated with the airways. Thus, local and/or systemically distributed BAFF affects Th1 and Th2 responses and impacts on the course of some T cell-mediated inflammatory reactions. Our results are consistent with the idea that BAFF augments T cell as well as B cell responses, particularly Th1-type responses. Results in BAFF Tg mice may reflect the situation in certain autoimmune patients or virally infected individuals, because BAFF levels in blood are comparable.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association of Immunologists
dc.publisher.placeUnited States
dc.publisher.urihttp://www.jimmunol.org/content/174/9/5537.abstract
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom5537
dc.relation.ispartofpageto5544
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of Immunology
dc.relation.ispartofvolume174
dc.rights.retentionY
dc.subject.fieldofresearchCellular Immunology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110704
dc.subject.fieldofresearchcode1107
dc.titleBAFF Augments Certain Th1-Associated Inflammatory Responses
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorRolph, Michael S.


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