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dc.contributor.authorGuo, Jiagang
dc.contributor.authorLi, Yuesheng
dc.contributor.authorGray, Darren
dc.contributor.authorNing, An
dc.contributor.authorHu, Guanghan
dc.contributor.authorChen, Honggen
dc.contributor.authorM. Davis, George
dc.contributor.authorC. Sleigh, Adrian
dc.contributor.authorFeng, ZHeng
dc.contributor.authorP. McManus, Donald
dc.contributor.authorWilliams, Gail M.
dc.date.accessioned2017-05-03T14:01:22Z
dc.date.available2017-05-03T14:01:22Z
dc.date.issued2006
dc.identifier.issn00029637
dc.identifier.urihttp://hdl.handle.net/10072/54977
dc.description.abstractSchistosomiasis japonica is a zoonosis of major public health importance in southern China. We undertook a drug intervention to test the hypothesis that buffalo are major reservoirs for human infection in the marshlands/lake areas, where one million people are infected. We compared human and buffalo infection rates and intensity in an intervention village (Jishan), where humans and buffalo were treated with praziquantel, and a control village (Hexi), where only humans were treated, in the Poyang Lake region. Over the four-year study, human incidence in Jishan decreased but increased in Hexi. Adjustment of incidence by age, sex, water exposure, year, and village further confirmed the decreased human infection in Jishan. Chemotherapy for buffaloes resulted in a decrease in buffalo infection rates in Jishan, which coincided with the reduction in human infection rates there in the last two years of the study. Mathematical modeling predicted that buffalo are responsible for 75% of human transmission in Jishan.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent465222 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.publisher.placeUnited States
dc.publisher.urihttp://www.ajtmh.org/content/74/2/335.abstract
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom335
dc.relation.ispartofpageto341
dc.relation.ispartofissue2
dc.relation.ispartofjournalAmerican Journal of Tropical Medicine and Hygiene
dc.relation.ispartofvolume74
dc.rights.retentionY
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111706
dc.subject.fieldofresearchcode11
dc.titleA drug-based intervention study on the importance of buffaloes for human Schistosoma japonicum infection around Poyang Lake, Peoples’ Republic of China.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2006 American Society of Tropical Medicine and Hygiene. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2015-06-01T23:37:41Z
gro.hasfulltextFull Text
gro.griffith.authorGray, Darren


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