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dc.contributor.authorShabman, Reed S.
dc.contributor.authorMorrison, Thomas E.
dc.contributor.authorMoore, Christopher
dc.contributor.authorWhite, Laura
dc.contributor.authorSuthar, Mehul S.
dc.contributor.authorHueston, Linda
dc.contributor.authorRulli, Nestor
dc.contributor.authorLidbury, Brett
dc.contributor.authorTing, Jenny P.-Y.
dc.contributor.authorMahalingam, Suresh
dc.contributor.authorHeise, Mark T.
dc.date.accessioned2018-11-07T00:55:31Z
dc.date.available2018-11-07T00:55:31Z
dc.date.issued2007
dc.date.modified2013-12-15T22:19:29Z
dc.identifier.issn0022538Xen_US
dc.identifier.doi10.1128/JVI.01590-06en_US
dc.identifier.urihttp://hdl.handle.net/10072/55004
dc.description.abstractDendritic cells (DCs) are an important early target cell for many mosquito-borne viruses, and in many cases mosquito-cell-derived arboviruses more efficiently infect DCs than viruses derived from mammalian cells. However, whether mosquito-cell-derived viruses differ from mammalian-cell-derived viruses in their ability to induce antiviral responses in the infected dendritic cell has not been evaluated. In this report, alphaviruses, which are mosquito-borne viruses that cause diseases ranging from encephalitis to arthritis, were used to determine whether viruses grown in mosquito cells differed from mammalian-cell-derived viruses in their ability to induce type I interferon (IFN) responses in infected primary dendritic cells. Consistent with previous results, mosquito-cell-derived Ross River virus (mos-RRV) and Venezuelan equine encephalitis virus (mos-VEE) exhibited enhanced infection of primary myeloid dendritic cells (mDCs) compared to mammalian-cell-derived virus preparations. However, unlike the mammalian-cell-derived viruses, which induced high levels of type I IFN in the infected mDC cultures, mos-RRV and mos-VEE were poor IFN inducers. Furthermore, the poor IFN induction by mos-RRV contributed to the enhanced infection of mDCs by mos-RRV. These results suggest that the viruses initially delivered by the mosquito vector differ from those generated in subsequent rounds of replication in the host, not just with respect to their ability to infect dendritic cells but also in their ability to induce or inhibit antiviral type I IFN responses. This difference may have an important impact on the mosquito-borne virus's ability to successfully make the transition from the arthropod vector to the vertebrate host.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom237en_US
dc.relation.ispartofpageto247en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalJournal of Virologyen_US
dc.relation.ispartofvolume81en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Virologyen_US
dc.subject.fieldofresearchcode110804en_US
dc.titleDifferential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-Cell-Derived Alphavirusesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPublisheden_US
gro.rights.copyright© 2007 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2007
gro.hasfulltextFull Text


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