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  • The adipocyte fatty acid–binding protein aP2 is required in allergic airway inflammation

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    Author(s)
    O.V. Shum, Bennett
    Mackay, Charles R.
    Z. Gorgun, Cem
    J. Frost, Melinda
    K. Kumar, Rakesh
    S. Hotamisligil, Gökhan
    S. Rolph, Michael
    Griffith University Author(s)
    Rolph, Michael S.
    Year published
    2006
    Metadata
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    Abstract
    The adipocyte fatty acid-binding protein aP2 regulates systemic glucose and lipid metabolism. We report that aP2, in addition to being abundantly expressed by adipocytes, is also expressed by human airway epithelial cells and shows a striking upregulation following stimulation of epithelial cells with the Th2 cytokines IL-4 and IL-13. Regulation of aP2 mRNA expression by Th2 cytokines was highly dependent on STAT6, a transcription factor with a major regulatory role in allergic inflammation. We examined aP2-deficient mice in a model of allergic airway inflammation and found that infiltration of leukocytes, especially ...
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    The adipocyte fatty acid-binding protein aP2 regulates systemic glucose and lipid metabolism. We report that aP2, in addition to being abundantly expressed by adipocytes, is also expressed by human airway epithelial cells and shows a striking upregulation following stimulation of epithelial cells with the Th2 cytokines IL-4 and IL-13. Regulation of aP2 mRNA expression by Th2 cytokines was highly dependent on STAT6, a transcription factor with a major regulatory role in allergic inflammation. We examined aP2-deficient mice in a model of allergic airway inflammation and found that infiltration of leukocytes, especially eosinophils, into the airways was highly dependent on aP2 function. T cell priming was unaffected by aP2 deficiency, suggesting that aP2 was acting locally within the lung, and analysis of bone marrow chimeras implicated non-hematopoietic cells, most likely bronchial epithelial cells, as the site of action of aP2 in allergic airway inflammation. Thus, aP2 regulates allergic airway inflammation and may provide a link between fatty acid metabolism and asthma.
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    Journal Title
    Journal of Clinical Investigation
    Volume
    116
    Issue
    8
    DOI
    https://doi.org/10.1172/JCI24767
    Copyright Statement
    © 2006 American Society for Clinical Investigation (ASCI). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Allergy
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/55006
    Collection
    • Journal articles

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