Show simple item record

dc.contributor.authorO.V. Shum, Bennett
dc.contributor.authorMackay, Charles R.
dc.contributor.authorZ. Gorgun, Cem
dc.contributor.authorJ. Frost, Melinda
dc.contributor.authorK. Kumar, Rakesh
dc.contributor.authorS. Hotamisligil, Gökhan
dc.contributor.authorS. Rolph, Michael
dc.date.accessioned2017-05-03T16:02:14Z
dc.date.available2017-05-03T16:02:14Z
dc.date.issued2006
dc.date.modified2013-12-15T22:20:32Z
dc.identifier.issn00219738
dc.identifier.doi10.1172/JCI24767
dc.identifier.urihttp://hdl.handle.net/10072/55006
dc.description.abstractThe adipocyte fatty acid-binding protein aP2 regulates systemic glucose and lipid metabolism. We report that aP2, in addition to being abundantly expressed by adipocytes, is also expressed by human airway epithelial cells and shows a striking upregulation following stimulation of epithelial cells with the Th2 cytokines IL-4 and IL-13. Regulation of aP2 mRNA expression by Th2 cytokines was highly dependent on STAT6, a transcription factor with a major regulatory role in allergic inflammation. We examined aP2-deficient mice in a model of allergic airway inflammation and found that infiltration of leukocytes, especially eosinophils, into the airways was highly dependent on aP2 function. T cell priming was unaffected by aP2 deficiency, suggesting that aP2 was acting locally within the lung, and analysis of bone marrow chimeras implicated non-hematopoietic cells, most likely bronchial epithelial cells, as the site of action of aP2 in allergic airway inflammation. Thus, aP2 regulates allergic airway inflammation and may provide a link between fatty acid metabolism and asthma.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1047466 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Clinical Investigation
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2183
dc.relation.ispartofpageto2192
dc.relation.ispartofissue8
dc.relation.ispartofjournalJournal of Clinical Investigation
dc.relation.ispartofvolume116
dc.rights.retentionY
dc.subject.fieldofresearchAllergy
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110701
dc.subject.fieldofresearchcode11
dc.titleThe adipocyte fatty acid–binding protein aP2 is required in allergic airway inflammation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2006 American Society for Clinical Investigation (ASCI). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2006
gro.hasfulltextFull Text
gro.griffith.authorRolph, Michael S.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record