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dc.contributor.authorLam, KY
dc.contributor.authorLo, CY
dc.contributor.editorDr. J A Franklyn, Dr. J Connell
dc.date.accessioned2006-07-06
dc.date.accessioned2017-03-02T00:36:05Z
dc.date.available2015-06-05T03:50:34Z
dc.date.available2017-03-02T00:36:05Z
dc.date.issued2001
dc.identifier.issn0300-0664
dc.identifier.doi10.1046/j.1365-2265.2001.01266.x
dc.identifier.urihttp://hdl.handle.net/10072/55082
dc.description.abstractOBJECTIVE Tuberculosis is potentially fatal and adrenal gland involvement is uncommonly reported. The aims of the current study were to define the characteristics of tuberculosis in hospitalized patients and to analyse the features of adrenal tuberculosis. DESIGN Retrospective analysis of autopsies and adrenalectomies. Patients 13 762 patients (13492 at autopsies and 270 at adrenalectomy). MEASUREMENTS The presence of active tuberculosis, the predisposing factors, the pathological features and organs of involvement were examined. RESULTS Active tuberculosis was present in 871 patients (6·5% of all 13492 autopsies). It was first diagnosed in 70% of these patients during autopsy. Cancers and a history of recent major operations were the 2 main concomitant factors in the patients with tuberculosis. Extra-pulmonary tuberculosis was seen in 261 patients (30%). The five most common extra-pulmonary sites of tuberculosis were the liver, spleen, kidney, bone and adrenal gland. Adrenal tuberculosis was seen in 52 of the 871 patients (6%) with active tuberculosis at autopsy and in 3 patients at adrenalectomy. The adrenal gland was the only organ involved by active tuberculosis in 14 of these 55 patients (25%; 35 men, 20 women). Tuberculosis was evident on macroscopic examination of the adrenal glands in 46% of the patients. On histological examination, caseous necrosis and granulomatous inflammation with Langhan's giant cells were seen in 71% and 40% of patients, respectively. Seven patients presented with signs and symptoms of Addison's disease due to bilateral adrenal involvement. Langhan's giant cells were frequently seen in histological sections and bilateral enlargement of the adrenal glands was often noted. Fine needle aspiration cytology was not useful for diagnosing adrenal tuberculosis. CONCLUSION Unexpected and extra-pulmonary tuberculosis such as adrenal tuberculosis has been a common problem. A high index of suspicion, correct diagnosis and proper treatment are essential for the management of tuberculosis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.publisher.placeUK
dc.relation.ispartofpagefrom633
dc.relation.ispartofpageto639
dc.relation.ispartofissue5
dc.relation.ispartofjournalClinical Endocrinology
dc.relation.ispartofvolume54
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1114
dc.titleA critical examination of adrenal tuberculosis and a 28-year autopsy experience of active tuberculosis.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyGriffith Health Faculty
gro.date.issued2015-06-05T03:50:34Z
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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