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  • Dendritic cell biology during malaria

    Author(s)
    Wykes, Michelle
    Keighley, Caitlin
    Pinzon-Charry, Alberto
    Good, Michael F
    Griffith University Author(s)
    Good, Michael F.
    Year published
    2007
    Metadata
    Show full item record
    Abstract
    Malaria is an infectious disease that causes serious morbidity and mortality worldwide. The disease is associated with a variety of clinical syndromes ranging from asymptomatic to lethal infections involving anaemia, organ failure, pulmonary and cerebral disease. The molecular and cellular factors responsible for the differences in disease severity are poorly understood but parasite-specific immune responses are thought to play a critical role in pathogenesis. Dendritic cells have an essential role in linking innate and adaptive immune responses and here we review their role in the context of malaria.Malaria is an infectious disease that causes serious morbidity and mortality worldwide. The disease is associated with a variety of clinical syndromes ranging from asymptomatic to lethal infections involving anaemia, organ failure, pulmonary and cerebral disease. The molecular and cellular factors responsible for the differences in disease severity are poorly understood but parasite-specific immune responses are thought to play a critical role in pathogenesis. Dendritic cells have an essential role in linking innate and adaptive immune responses and here we review their role in the context of malaria.
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    Journal Title
    Cellular Microbiology
    Volume
    9
    Issue
    2
    DOI
    https://doi.org/10.1111/j.1462-5822.2006.00865.x
    Subject
    Microbiology
    Microbiology not elsewhere classified
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/55089
    Collection
    • Journal articles

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