Dendritic cell biology during malaria
Author(s)
Wykes, Michelle
Keighley, Caitlin
Pinzon-Charry, Alberto
Good, Michael F
Griffith University Author(s)
Year published
2007
Metadata
Show full item recordAbstract
Malaria is an infectious disease that causes serious morbidity and mortality worldwide. The disease is associated with a variety of clinical syndromes ranging from asymptomatic to lethal infections involving anaemia, organ failure, pulmonary and cerebral disease. The molecular and cellular factors responsible for the differences in disease severity are poorly understood but parasite-specific immune responses are thought to play a critical role in pathogenesis. Dendritic cells have an essential role in linking innate and adaptive immune responses and here we review their role in the context of malaria.Malaria is an infectious disease that causes serious morbidity and mortality worldwide. The disease is associated with a variety of clinical syndromes ranging from asymptomatic to lethal infections involving anaemia, organ failure, pulmonary and cerebral disease. The molecular and cellular factors responsible for the differences in disease severity are poorly understood but parasite-specific immune responses are thought to play a critical role in pathogenesis. Dendritic cells have an essential role in linking innate and adaptive immune responses and here we review their role in the context of malaria.
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Journal Title
Cellular Microbiology
Volume
9
Issue
2
Subject
Microbiology
Microbiology not elsewhere classified
Medical microbiology