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dc.contributor.authorTong, Y
dc.contributor.authorZhang, R
dc.contributor.authorNgo, SNT
dc.contributor.authorDavey, AK
dc.date.accessioned2017-05-03T14:06:01Z
dc.date.available2017-05-03T14:06:01Z
dc.date.issued2006
dc.date.modified2013-12-18T22:54:09Z
dc.identifier.issn0305-1870
dc.identifier.doi10.1111/j.1440-1681.2006.04419.x
dc.identifier.urihttp://hdl.handle.net/10072/55147
dc.description.abstract1The aim of the present study was to examine the effect of bacterial lipopolysaccharide (LPS) on the disposition of an organic anion transporting polypeptide and P-glycoprotein substrate in the rat isolated perfused liver.2Male Sprague-Dawley rats were divided into four groups. Three of the groups received 1, 2.5 or 5 mg/kg, i.p., Escherichia coli LPS in sterile saline. The fourth group received an equivalent volume of sterile saline i.p. Twenty-four hours after treatment, rats were anaesthetized and the liver isolated and perfused with fexofenadine at an initial concentration of 2000 ng/mL in a recirculating system. Perfusate and bile samples were collected for 60 min and the liver was collected at the end of the perfusion. Fexofenadine concentrations were determined by HPLC. Fexofenadine pharmacokinetic parameters, the final liver : perfusate (L : P) and bile : liver (B : L) concentration ratios were determined.3Injection of LPS changed the hepatic disposition of fexofenadine. The changes were most marked in the 5 mg/kg LPS group. Notably, clearance from the perfusate (CL) and into the bile (CLB; 5.9 ᠰ.6 and 1.24 ᠰ.20 mL/min, respectively), L : P (44 ᠱ1) and B : L (17 ᠲ) were all reduced (P < 0.05) in this group compared with control (CL 10.0 ᠱ.1 mL/min; CLB 2.7 ᠰ.5 mL/min; L : P 87 ᠱ4; and B : L 30 ᠴ).4In conclusion CL and CLB were reduced
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Asia
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom685
dc.relation.ispartofpageto689
dc.relation.ispartofissue8
dc.relation.ispartofjournalClinical and Experimental Pharmacology & Physiology
dc.relation.ispartofvolume33
dc.rights.retentionY
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchBasic pharmacology
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321401
dc.subject.fieldofresearchcode3208
dc.titleAlteration of fexofenadine disposition in the rat isolated perfused liver following injection of bacterial lipopolysaccharide
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorDavey, Andrew


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