Show simple item record

dc.contributor.authorMileusnic, R
dc.contributor.authorLancashire, CL
dc.contributor.authorJohnston, ANB
dc.contributor.authorRose, SPR
dc.date.accessioned2006-07-28
dc.date.accessioned2013-12-19T22:25:56Z
dc.date.accessioned2017-03-02T00:36:48Z
dc.date.available2017-03-02T00:36:48Z
dc.date.issued2000
dc.date.modified2013-12-19T22:25:56Z
dc.identifier.issn0953-816X
dc.identifier.doi10.1111/j.1460-9568.2000.01344.x
dc.identifier.urihttp://hdl.handle.net/10072/55184
dc.description.abstractThe amyloid beta/A4 protein precursor (APP) has been shown to be implicated in age-associated plastic changes at synapses that might contribute to memory loss in Alzheimer's disease. As APP has previously been reported to have multiple functions during normal development, we have employed a one-trial passive avoidance task in day-old chicks to study its role in the process of memory formation. Administration of anti-APP antibodies, injected 30 min pretraining, prevented memory for a one-trial passive avoidance task in day-old chicks without effects on general behaviour or initial acquisition. Amnesia was apparent by 30 min post-training and lasted for at least 24 h. The same result was obtained by down-regulation of APP expression by APP-antisense, injected 8-12 h pretraining. However, injections of anti-APP antibodies or APP antisense at later post-training time did not cause amnesia for the task. Unlike antibodies and antisense, injection of the APP328-332 pentapeptide, in either orientation, 30 min pretraining, rescued the memory and prevented antisense-induced amnesia. The post-training time within which the antibody- and antisense-induced amnesia, and within which the APP peptides prevent amnesia, correspond to that during which memory formation is vulnerable to disruption of the putative signal transduction functions of APP. These results suggest that: (i) APP is required during an early phase of memory formation, and (ii) the memory enhancing effect of secretory APP is localized within a 5-mer sequence of growth-promoting domain.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell publishing
dc.publisher.placeOxon
dc.relation.ispartofpagefrom4487
dc.relation.ispartofpageto4495
dc.relation.ispartofjournalEuropean Journal of Neuroscience
dc.relation.ispartofvolume12
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.titleAPP is required during an early phase of memory formation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyEskitis, Inst Cell&Molecular Therapies
gro.date.issued2000
gro.hasfulltextNo Full Text
gro.griffith.authorJohnston, Amy N.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record