A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Al Olama, Ali Amin; Kote-Jarai, Zsofia; Schumacher, Fredrick R; Wiklund, Fredrik; Berndt, Sonja I; Benlloch, Sara; Giles, Graham G; Severi, Gianluca; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Hunter, David J; Henderson, Brian E; Thun, Michael J; Gaziano, Michael; Giovannucci, Edward L; Siddiq, Afshan; Travis, Ruth C; Cox, David G; Canzian, Federico; Riboli, Elio; Key, Timothy J; Andriole, Gerald; Albanes, Demetrius; Hayes, Richard B; Schleutker, Johanna; Auvinen, Anssi; Tammela, Teuvo LJ; Weischer, Maren; Stanford, Janet L; Ostrander, Elaine A; Cybulski, Cezary; Lubinski, Jan; Thibodeau, Stephen N; Schaid, Daniel J; Sorensen, Karina D; Batra, Jyotsna; Clements, Judith A; Chambers, Suzanne; Aitken, Joanne; Gardiner, Robert A; Maier, Christiane; Vogel, Walther; Doerk, Thilo; Brenner, Hermann; Habuchi, Tomonori; Ingles, Sue; John, Esther M; Dickinson, Joanne L; Cannon-Albright, Lisa; Teixeira, Manuel R; Kaneva, Radka; Zhang, Hong-Wei; Lu, Yong-Jie; Park, Jong Y; Cooney, Kathleen A; Muir, Kenneth R; Leongamornlert, Daniel A; Saunders, Edward; Tymrakiewicz, Malgorzata; Mahmud, Nadiya; Guy, Michelle; Govindasami, Koveela; O'Brien, Lynne T; Wilkinson, Rosemary A; Hall, Amanda L; Sawyer, Emma J; Dadaev, Tokhir; Morrison, Jonathan; Dearnaley, David P; Horwich, Alan; Huddart, Robert A; Khoo, Vincent S; Parker, Christopher C; Van As, Nicholas; Woodhouse, Christopher J; Thompson, Alan; Dudderidge, Tim; Ogden, Chris; Cooper, Colin S; Lophatonanon, Artitaya; Southey, Melissa C; Hopper, John L; English, Dallas; Virtamo, Jarmo; Le Marchand, Loic; Campa, Daniele; Kaaks, Rudolf; Lindstrom, Sara; Diver, W Ryan; Gapstur, Susan; Yeager, Meredith; Cox, Angela; Stern, Mariana C; Corral, Roman; Aly, Markus; Isaacs, William; Adolfsson, Jan; Xu, Jianfeng; Zheng, S Lilly; Wahlfors, Tiina; Taari, Kimmo; Kujala, Paula; Klarskov, Peter; Nordestgaard, Borge G; Roder, M Andreas; Frikke-Schmidt, Ruth; Bojesen, Stig E; FitzGerald, Liesel M; Kolb, Suzanne; Kwon, Erika M; Karyadi, Danielle M; Orntoft, Torben Falck; Borre, Michael; Rinckleb, Antje; Luedeke, Manuel; Herkommer, Kathleen; Meyer, Andreas; Serth, Juergen; Marthick, James R; Patterson, Briony; Wokolorczyk, Dominika; Spurdle, Amanda; Lose, Felicity; McDonnell, Shannon K; Joshi, Amit D; Shahabi, Ahva; Pinto, Pedro; Santos, Joana; Ray, Ana; Sellers, Thomas A; Lin, Hui-Yi; Stephenson, Robert A; Teerlink, Craig; Muller, Heiko; Rothenbacher, Dietrich; Tsuchiya, Norihiko; Narita, Shintaro; Cao, Guang-Wen; Slavov, Chavdar; Mitev, Vanio; Chanock, Stephen; Gronberg, Henrik; Haiman, Christopher A; Kraft, Peter; Easton, Douglas F; Eeles, Rosalind A

doi:10.1093/hmg/dds425

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Author(s)

Al Olama, Ali Amin

Kote-Jarai, Zsofia

Schumacher, Fredrick R

Wiklund, Fredrik

Berndt, Sonja I

Benlloch, Sara

Giles, Graham G

Severi, Gianluca

Neal, David E

Hamdy, Freddie C

Donovan, Jenny L

Hunter, David J

Henderson, Brian E

Thun, Michael J

Gaziano, Michael

Giovannucci, Edward L

Siddiq, Afshan

Travis, Ruth C

Cox, David G

Canzian, Federico

Riboli, Elio

Key, Timothy J

Andriole, Gerald

Albanes, Demetrius

Hayes, Richard B

Schleutker, Johanna

Auvinen, Anssi

Tammela, Teuvo LJ

Weischer, Maren

Stanford, Janet L

Ostrander, Elaine A

Cybulski, Cezary

Lubinski, Jan

Thibodeau, Stephen N

Schaid, Daniel J

Sorensen, Karina D

Batra, Jyotsna

Clements, Judith A

Chambers, Suzanne

Aitken, Joanne

Gardiner, Robert A

Maier, Christiane

Vogel, Walther

Doerk, Thilo

Brenner, Hermann

Habuchi, Tomonori

Ingles, Sue

John, Esther M

Dickinson, Joanne L

Cannon-Albright, Lisa

Teixeira, Manuel R

Kaneva, Radka

Zhang, Hong-Wei

Lu, Yong-Jie

Park, Jong Y

Cooney, Kathleen A

Muir, Kenneth R

Leongamornlert, Daniel A

Saunders, Edward

Tymrakiewicz, Malgorzata

Mahmud, Nadiya

Guy, Michelle

Govindasami, Koveela

O'Brien, Lynne T

Wilkinson, Rosemary A

Hall, Amanda L

Sawyer, Emma J

Dadaev, Tokhir

Morrison, Jonathan

Dearnaley, David P

Horwich, Alan

Huddart, Robert A

Khoo, Vincent S

Parker, Christopher C

Van As, Nicholas

Woodhouse, Christopher J

Thompson, Alan

Dudderidge, Tim

Ogden, Chris

Cooper, Colin S

Lophatonanon, Artitaya

Southey, Melissa C

Hopper, John L

English, Dallas

Virtamo, Jarmo

Le Marchand, Loic

Campa, Daniele

Kaaks, Rudolf

Lindstrom, Sara

Diver, W Ryan

Gapstur, Susan

Yeager, Meredith

Cox, Angela

Stern, Mariana C

Corral, Roman

Aly, Markus

Isaacs, William

Adolfsson, Jan

Xu, Jianfeng

Zheng, S Lilly

Wahlfors, Tiina

Taari, Kimmo

Kujala, Paula

Klarskov, Peter

Nordestgaard, Borge G

Roder, M Andreas

Frikke-Schmidt, Ruth

Bojesen, Stig E

FitzGerald, Liesel M

Kolb, Suzanne

Kwon, Erika M

Karyadi, Danielle M

Orntoft, Torben Falck

Borre, Michael

Rinckleb, Antje

Luedeke, Manuel

Herkommer, Kathleen

Meyer, Andreas

Serth, Juergen

Marthick, James R

Patterson, Briony

Wokolorczyk, Dominika

Spurdle, Amanda

Lose, Felicity

McDonnell, Shannon K

Joshi, Amit D

Shahabi, Ahva

Pinto, Pedro

Santos, Joana

Ray, Ana

Sellers, Thomas A

Lin, Hui-Yi

Stephenson, Robert A

Teerlink, Craig

Muller, Heiko

Rothenbacher, Dietrich

Tsuchiya, Norihiko

Narita, Shintaro

Cao, Guang-Wen

Slavov, Chavdar

Mitev, Vanio

Chanock, Stephen

Gronberg, Henrik

Haiman, Christopher A

Kraft, Peter

Easton, Douglas F

Eeles, Rosalind A

Griffith University Author(s)

Chambers, Suzanne K.

Year published

2013

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Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four genome-wide association studies (GWAS) including 5,953 cases of aggressive PrCa and 11,463 controls (men without PrCa). We computed association tests for ~2.6M SNPs and followed up the most significant SNPs by genotyping 49,121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association ...
View more >Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four genome-wide association studies (GWAS) including 5,953 cases of aggressive PrCa and 11,463 controls (men without PrCa). We computed association tests for ~2.6M SNPs and followed up the most significant SNPs by genotyping 49,121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa (OR=1.12 (95% CI 1.03-1.21), P=1.4x10-8). This report describes a genetic variant which is associated with aggressive prostate cancer, which is a type of prostate cancer associated with a poorer prognosis
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Journal Title

Human Molecular Genetics

Volume

Issue

DOI

https://doi.org/10.1093/hmg/dds425

Copyright Statement

© 2013 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Molecular Genetics following peer review. The definitive publisher-authenticated version, A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease, Human Molecular Genetics, Vol.22 (2), 2013, pp. 408-415 is available online at: dx.doi.org/10.1093/hmg/dds425.

Subject

Biological sciences

Biomedical and clinical sciences

Publication URI

http://hdl.handle.net/10072/55309

Collection

Journal articles