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dc.contributor.authorAl-Sanea, MM
dc.contributor.authorEl-Deeb, IM
dc.contributor.authorLee, SH
dc.date.accessioned2017-05-03T15:59:03Z
dc.date.available2017-05-03T15:59:03Z
dc.date.issued2013
dc.date.modified2014-01-07T05:08:23Z
dc.identifier.issn0253-2964
dc.identifier.urihttp://hdl.handle.net/10072/55327
dc.description.abstractA new series of 4-(2-(substituted)pyridin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazoles (4a-f) and their 1,2-isoxazole analogues (5a-f) has been rationally designed, synthesized and screened against both ROS and MAPK14 kinases. Compounds 4b, 4c and 4e showed moderate inhibitions against both ROS and MAPK14 kinases. Compound 4e has showed the strongest inhibitions with IC50 values of 1.25 占and 3.00 占against ROS and MAPK14 kinases, respectively. A brief structure-activity relationship study and a molecular modeling study were made revealing a group of essential structural features for good kinase inhibitory activity within this new class of kinase inhibitors.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherKorean Chemical Society
dc.publisher.placeSouth Korea
dc.publisher.urihttp://newjournal.kcsnet.or.kr/url/bkcs/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom437
dc.relation.ispartofpageto442
dc.relation.ispartofissue2
dc.relation.ispartofjournalBulletin of the Korean Chemical Society
dc.relation.ispartofvolume34
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340401
dc.titleDesign, Synthesis and in-vitro Screening of New 1H-Pyrazole and 1,2-Isoxazole Derivatives as Potential Inhibitors for ROS and MAPK14 Kinases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorEl-Deeb, Ibrahim Mustafa


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