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  • Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine

    Author(s)
    Curtain, Rob
    Lea, Rodney
    Quinlan, Sharon
    Bellis, Claire
    Tajouri, Lotfi
    Hughes, Roger
    MacMillan, John
    Griffiths, Lyn
    Griffith University Author(s)
    Hughes, Roger M.
    MacMillan, John C.
    Tajouri, Lotfi
    Griffiths, Lyn
    Quinlan, Sharon A.
    Lea, Rodney A.
    Curtain, Rob
    Bellis, Claire
    Year published
    2004
    Metadata
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    Abstract
    The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene on chromosome 19p13.2 performing an association analysis in 244 typical migraine-affected patients, 151 suffering from migraine with aura (MA), 96 with migraine without aura (MO) and 244 unaffected controls. The populations consisted of Caucasians only, and controls were age- and sex-matched. The results showed no significant difference between groups for allele frequency distributions of the (TA)n polymorphism even after ...
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    The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene on chromosome 19p13.2 performing an association analysis in 244 typical migraine-affected patients, 151 suffering from migraine with aura (MA), 96 with migraine without aura (MO) and 244 unaffected controls. The populations consisted of Caucasians only, and controls were age- and sex-matched. The results showed no significant difference between groups for allele frequency distributions of the (TA)n polymorphism even after separation of the migraine-affected individuals into subgroups of MA and MO affected patients. This is in contradiction to Mochi et al. [Mochi M, Cevoli S, Cortelli P, Pierangeli G, Scapoli C, Soriani S, Montagna P. Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migrane without aura. J Neurol Sci 2003; 213 (1-2): 7-10.] who found a positive association of this variant with MO. Our study discusses possible differences between the two studies and extends this research by investigating circulating cholesterol levels in a migraine-affected population
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    Journal Title
    Journal of the Neurological Sciences
    Volume
    227
    Issue
    1
    DOI
    https://doi.org/10.1016/j.jns.2004.08.010
    Subject
    Clinical Sciences
    Neurosciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/5536
    Collection
    • Journal articles

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