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dc.contributor.authorColson, Natalieen_US
dc.contributor.authorLea, Rodneyen_US
dc.contributor.authorQuinlan, Sharonen_US
dc.contributor.authorMacMillan, Johnen_US
dc.contributor.authorGriffiths, Lynen_US
dc.date.accessioned2017-04-24T09:13:43Z
dc.date.available2017-04-24T09:13:43Z
dc.date.issued2004en_US
dc.date.modified2010-08-09T07:16:47Z
dc.identifier.issn13646745en_US
dc.identifier.doi10.1007/s10048-004-0181-4en_AU
dc.identifier.urihttp://hdl.handle.net/10072/5539
dc.description.abstractMigraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in hormone levels are associated with migraine onset in many sufferers of the disorder. Steroid hormones mediate their activity via hormone receptors, which have a wide tissue distribution. Estrogen receptors have been localized to the brain in regions considered to be involved in migraine pathogenesis. Hence it is possible that genetic variation in the estrogen receptor gene may play a role in migraine susceptibility. This study thus examined the estrogen receptor 1 (ESR ) gene for a potential role in migraine pathogenesis and susceptibility. A population-based cohort of 224 migraine sufferers and 224 matched controls were genotyped for the G594A polymorphism located in exon 8 of the ESR1 gene. Statistical analysis indicated a significant difference between migraineurs and non-migraineurs in both the allele frequencies (P=0.003) and genotype distributions (P=0.008) in this sample. An independent follow-up study was then undertaken using this marker in an additional population-based cohort of 260 migraine sufferers and 260 matched controls. This resulted in a significant association between the two groups with regard to allele frequencies (P=8ױ0-6) and genotype distributions (P=4ױ0-5). Our findings support the hypothesis that genetic variation in hormone receptors, in particular the ESR1 gene, may play a role in migraine.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent158565 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringer-Verlagen_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofpagefrom129en_US
dc.relation.ispartofpageto133en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalNeurogeneticsen_US
dc.relation.ispartofvolume5en_US
dc.subject.fieldofresearchcode270210en_US
dc.titleThe estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groupsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright 2004 Springer. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher : The original publication is available at www.springerlink.comen_AU
gro.date.issued2004
gro.hasfulltextFull Text


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    Contains articles published by Griffith authors in scholarly journals.

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