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dc.contributor.authorColson, NJ
dc.contributor.authorLea, RA
dc.contributor.authorQuinlan, S
dc.contributor.authorMacMillan, J
dc.contributor.authorGriffiths, LR
dc.date.accessioned2017-05-03T12:15:50Z
dc.date.available2017-05-03T12:15:50Z
dc.date.issued2004
dc.date.modified2010-08-09T07:16:47Z
dc.identifier.issn1364-6745
dc.identifier.doi10.1007/s10048-004-0181-4
dc.identifier.urihttp://hdl.handle.net/10072/5539
dc.description.abstractMigraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in hormone levels are associated with migraine onset in many sufferers of the disorder. Steroid hormones mediate their activity via hormone receptors, which have a wide tissue distribution. Estrogen receptors have been localized to the brain in regions considered to be involved in migraine pathogenesis. Hence it is possible that genetic variation in the estrogen receptor gene may play a role in migraine susceptibility. This study thus examined the estrogen receptor 1 (ESR ) gene for a potential role in migraine pathogenesis and susceptibility. A population-based cohort of 224 migraine sufferers and 224 matched controls were genotyped for the G594A polymorphism located in exon 8 of the ESR1 gene. Statistical analysis indicated a significant difference between migraineurs and non-migraineurs in both the allele frequencies (P=0.003) and genotype distributions (P=0.008) in this sample. An independent follow-up study was then undertaken using this marker in an additional population-based cohort of 260 migraine sufferers and 260 matched controls. This resulted in a significant association between the two groups with regard to allele frequencies (P=8ױ0-6) and genotype distributions (P=4ױ0-5). Our findings support the hypothesis that genetic variation in hormone receptors, in particular the ESR1 gene, may play a role in migraine.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent158565 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer-Verlag
dc.publisher.placeGermany
dc.relation.ispartofpagefrom129
dc.relation.ispartofpageto133
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeurogenetics
dc.relation.ispartofvolume5
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleThe estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2004 Springer. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher : The original publication is available at www.springerlink.com
gro.date.issued2004
gro.hasfulltextFull Text
gro.griffith.authorColson, Natalie J.


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