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dc.contributor.authorRutherford, S
dc.contributor.authorJohnson, MP
dc.contributor.authorGriffiths, LR
dc.date.accessioned2017-05-03T12:15:51Z
dc.date.available2017-05-03T12:15:51Z
dc.date.issued2004
dc.identifier.issn1552-4825
dc.identifier.doi10.1002/ajmg.a.20586
dc.identifier.urihttp://hdl.handle.net/10072/5540
dc.description.abstractInterest in chromosome 18 in essential hypertension comes from comparative mapping of rat blood pressure quantitative trait loci (QTL), familial orthostatic hypotensive syndrome studies, and essential hypertension pedigree linkage analyses indicating that a locus or loci on human chromosome 18 may play a role in hypertension development. To further investigate involvement of chromosome 18 in human essential hypertension, the present study utilized a linkage scan approach to genotype twelve microsatellite markers spanning human chromosome 18 in 177 Australian Caucasian hypertensive (HT) sibling pairs. Linkage analysis showed significant excess allele sharing of the D18S61 marker when analyzed with SPLINK (P?=?0.00012), ANALYZE (Sibpair) (P?=?0.0081), and also with MAPMAKER SIBS (P?=?0.0001). Similarly, the D18S59 marker also showed evidence for excess allele sharing when analyzed with SPLINK (P?=?0.016), ANALYZE (Sibpair) (P?=?0.0095), and with MAPMAKER SIBS (P?=?0.014). The adenylate cyclase activating polypeptide 1 gene (ADCYAP1) is involved in vasodilation and has been co-localized to the D18S59 marker. Results testing a microsatellite marker in the 3' untranslated region of ADCYAP1 in age and gender matched HT and normotensive (NT) individuals showed possible association with hypertension (P?=?0.038; Monte Carlo P?=?0.02), but not with obesity. The present study shows a chromosome 18 role in essential hypertension and indicates that the genomic region near the ADCYAP1 gene or perhaps the gene itself may be implicated. Further investigation is required to conclusively determine the extent to which ADCYAP1 polymorphisms are involved in essential hypertension.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom241
dc.relation.ispartofpageto247
dc.relation.ispartofjournalAmerican Journal of Medical Genetics
dc.relation.ispartofvolume126A
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode3202
dc.titleSibpair Studies Implicate Chromosome 18 in Essential Hypertension
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-02-04T04:26:34Z
gro.hasfulltextNo Full Text
gro.griffith.authorJohnson, Matthew P.
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorRutherford Siegel, Sue


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