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  • Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population

    Author(s)
    Tajouri, Lotfi
    Ferreira, Linda
    Ovcaric, Micky
    Curtain, Rob
    Lea, Rodney
    Csurhes, Peter
    P. Pender, Michael
    Griffiths, Lyn
    Griffith University Author(s)
    Tajouri, Lotfi
    Griffiths, Lyn
    Lea, Rodney A.
    Curtain, Rob
    Ovcaric, Micky
    Ferreira, Linda A.
    Year published
    2004
    Metadata
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    Abstract
    Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases (NOS) are a family of enzymes that control the production of nitric oxide. It is possible that neuronal NOS could be involved in MS pathophysiology and hence the nNOS gene is a potential candidate for involvement in disease susceptibility. The aim of this study was to determine whether allelic variation at the nNOS gene locus is associated with MS in an Australian cohort. DNA samples obtained from a Caucasian Australian population ...
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    Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases (NOS) are a family of enzymes that control the production of nitric oxide. It is possible that neuronal NOS could be involved in MS pathophysiology and hence the nNOS gene is a potential candidate for involvement in disease susceptibility. The aim of this study was to determine whether allelic variation at the nNOS gene locus is associated with MS in an Australian cohort. DNA samples obtained from a Caucasian Australian population affected with MS and an unaffected control population, matched for gender, age and ethnicity, were genotyped for a microsatellite polymorphism in the promoter region of the nNOS gene. Allele frequencies were compared using chi-squared based statistical analyses with significance tested by Monte Carlo simulation. Allelic analysis of MS cases and controls produced a chi-squared value of 5.63 with simulated P=0.96 (OR(max)=1.41, 95% CI: 0.926-2.15). Similarly, a Mann-Whitney U analysis gave a non-significant P-value of 0.377 for allele distribution. No differences in allele frequencies were observed for gender or clinical course subtype (P>0.05). Statistical analysis indicated that there is no association of this nNOS variant and MS and hence the gene does not appear to play a genetically significant role in disease susceptibility.
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    Journal Title
    Journal of the Neurological Sciences
    Volume
    218
    Publisher URI
    http://www.elsevier.com/wps/find/journaldescription.cws_home/506078/description#description
    DOI
    https://doi.org/10.1016/j.jns.2003.10.006
    Copyright Statement
    © 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online
    Subject
    Clinical Sciences
    Neurosciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/5542
    Collection
    • Journal articles

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