• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • The open window of susceptibility to infection after acute exercise in healthy young male elite athletes

    Thumbnail
    View/Open
    87171_1.pdf (342.1Kb)
    Author(s)
    Kakanis, M.
    Peake, J.
    Hooper, S.
    Gray, Bon
    Marshall-Gradisnik, S.
    Griffith University Author(s)
    Marshall-Gradisnik, Sonya M.
    Year published
    2010
    Metadata
    Show full item record
    Abstract
    Introduction: The "open window" theory describes the purported short-term suppression of the immune system following an acute bout of endurance exercise, which may lead to an increased susceptibility to upper respiratory illness (URI). Although many studies have found evidence of a decrease in immune function after intense exercise, these studies have not documented the changes in immune function past 2 h after the completion of exercise. It is unclear whether these immune functions return to resting levels before a second bout of exercise on the same day. Methodology: Ten male "A" grade cyclists (age 24.2 ᠵ.3 years; body ...
    View more >
    Introduction: The "open window" theory describes the purported short-term suppression of the immune system following an acute bout of endurance exercise, which may lead to an increased susceptibility to upper respiratory illness (URI). Although many studies have found evidence of a decrease in immune function after intense exercise, these studies have not documented the changes in immune function past 2 h after the completion of exercise. It is unclear whether these immune functions return to resting levels before a second bout of exercise on the same day. Methodology: Ten male "A" grade cyclists (age 24.2 ᠵ.3 years; body mass 73.8 ᠶ.5 kg; VO2peak 65.9 ᠷ.1 mL kg-1 min-1) exercised for 2 h at 90% of their second ventilatory threshold. Blood samples were collected before, immediately after, and 2, 4, 6, 8, and 24 h after exercise. Immune variables examined included total leucocyte counts, neutrophil function, lymphocyte subset counts, natural killer (NK) cytotoxic activity, and NK cell phenotypes. Results: Total lymphocyte numbers increased from before to immediately after exercise (p < 0.01), decreased at 2 h after exercise (p < 0.001), and returned to resting level 24 h after exercise. CD4+ T-cell counts increased from before to 4 h (p < 0.05) and 6 h after exercise (p < 0.01), and remained elevated at 24 h after exercise. NK cell numbers decreased significantly from before to 4, 6 and 8 h after exercise (p < 0.05), and returned to resting level by 24 h after exercise. CD56brightCD16- NK cell counts increased from before to immediately after exercise (p < 0.01) and returned to baseline level by 2 h after exercise. NK cytotoxic activity and neutrophil oxidative burst activity did not change significantly after exercise. However, neutrophil cell counts increased from before to immediately after exercise (p < 0.05) and 2 h after exercise (p < 0.01), and returned to resting level by 24 h after exercise. Neutrophil phagocytic function decreased from 2 h to 6 h and 8 h after exercise (p < 0.05). Eosinophil cell counts increased from 2 h to 6 h and 8 h after exercise (p < 0.05). Conclusion: This is the first study to show changes in immune cell counts and function for up to 8 h after exercise. These long-lasting changes in total lymphocyte and NK cell counts and neutrophil phagocytic function following exercise may contribute to the risk of URI associated with intense endurance exercise training in athletes who train more than once a day.
    View less >
    Journal Title
    Journal of Science and Medicine in Sport
    Volume
    13
    DOI
    https://doi.org/10.1016/j.jsams.2010.10.642
    Copyright Statement
    © 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Cellular Immunology
    Human Movement and Sports Sciences
    Medical Physiology
    Public Health and Health Services
    Publication URI
    http://hdl.handle.net/10072/55585
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander