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dc.contributor.authorKakanis, M.
dc.contributor.authorPeake, J.
dc.contributor.authorHooper, S.
dc.contributor.authorGray, Bon
dc.contributor.authorMarshall-Gradisnik, S.
dc.date.accessioned2017-05-03T16:11:05Z
dc.date.available2017-05-03T16:11:05Z
dc.date.issued2010
dc.date.modified2014-03-24T04:34:18Z
dc.identifier.issn14402440
dc.identifier.doi10.1016/j.jsams.2010.10.642
dc.identifier.urihttp://hdl.handle.net/10072/55585
dc.description.abstractIntroduction: The "open window" theory describes the purported short-term suppression of the immune system following an acute bout of endurance exercise, which may lead to an increased susceptibility to upper respiratory illness (URI). Although many studies have found evidence of a decrease in immune function after intense exercise, these studies have not documented the changes in immune function past 2 h after the completion of exercise. It is unclear whether these immune functions return to resting levels before a second bout of exercise on the same day. Methodology: Ten male "A" grade cyclists (age 24.2 ᠵ.3 years; body mass 73.8 ᠶ.5 kg; VO2peak 65.9 ᠷ.1 mL kg-1 min-1) exercised for 2 h at 90% of their second ventilatory threshold. Blood samples were collected before, immediately after, and 2, 4, 6, 8, and 24 h after exercise. Immune variables examined included total leucocyte counts, neutrophil function, lymphocyte subset counts, natural killer (NK) cytotoxic activity, and NK cell phenotypes. Results: Total lymphocyte numbers increased from before to immediately after exercise (p < 0.01), decreased at 2 h after exercise (p < 0.001), and returned to resting level 24 h after exercise. CD4+ T-cell counts increased from before to 4 h (p < 0.05) and 6 h after exercise (p < 0.01), and remained elevated at 24 h after exercise. NK cell numbers decreased significantly from before to 4, 6 and 8 h after exercise (p < 0.05), and returned to resting level by 24 h after exercise. CD56brightCD16- NK cell counts increased from before to immediately after exercise (p < 0.01) and returned to baseline level by 2 h after exercise. NK cytotoxic activity and neutrophil oxidative burst activity did not change significantly after exercise. However, neutrophil cell counts increased from before to immediately after exercise (p < 0.05) and 2 h after exercise (p < 0.01), and returned to resting level by 24 h after exercise. Neutrophil phagocytic function decreased from 2 h to 6 h and 8 h after exercise (p < 0.05). Eosinophil cell counts increased from 2 h to 6 h and 8 h after exercise (p < 0.05). Conclusion: This is the first study to show changes in immune cell counts and function for up to 8 h after exercise. These long-lasting changes in total lymphocyte and NK cell counts and neutrophil phagocytic function following exercise may contribute to the risk of URI associated with intense endurance exercise training in athletes who train more than once a day.
dc.description.publicationstatusYes
dc.format.extent350374 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome-85
dc.relation.ispartofpagetoe-86
dc.relation.ispartofjournalJournal of Science and Medicine in Sport
dc.relation.ispartofvolume13
dc.rights.retentionY
dc.subject.fieldofresearchCellular Immunology
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110704
dc.subject.fieldofresearchcode1106
dc.subject.fieldofresearchcode1116
dc.subject.fieldofresearchcode1117
dc.titleThe open window of susceptibility to infection after acute exercise in healthy young male elite athletes
dc.typeJournal article
dc.type.descriptionC3 - Articles (Letter/ Note)
dc.type.codeC - Journal Articles
gro.rights.copyright© 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorMarshall-Gradisnik, Sonya M.


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