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dc.contributor.authorHerrero, Lara J
dc.contributor.authorZakhary, Andrew
dc.contributor.authorGahan, Michelle E
dc.contributor.authorNelson, Michelle A
dc.contributor.authorHerring, Belinda L
dc.contributor.authorHapel, Andrew J
dc.contributor.authorKeller, Paul A
dc.contributor.authorObeysekera, Maheshi
dc.contributor.authorChen, Weiqiang
dc.contributor.authorSheng, Kuo-Ching
dc.contributor.authorTaylor, Adam
dc.contributor.authorWolf, Stefan
dc.contributor.authorBettadapura, Jayaram
dc.contributor.authorBroor, Shobha
dc.contributor.authorDar, Lalit
dc.contributor.authorMahalingam, Suresh
dc.description.abstractDengue virus (DV) is the most widespread arbovirus, being endemic in over 100 countries, and is estimated to cause 50 million infections annually. Viral factors, such as the genetic composition of the virus strain can play a role in determining the virus virulence and subsequent clinical disease severity. Virus vector competence plays an integral role in virus transmission and is a critical factor in determining the severity and impact of DV outbreaks. Host genetic variations in immune-related genes, including the human leukocyte antigen, have also been shown to correlate with clinical disease and thus may play a role in regulating disease severity. The host's immune system, however, appears to be the primary factor in DV pathogenesis with the delicate interplay of innate and acquired immunity playing a crucial role. Although current research of DV pathogenesis has been limited by the lack of an appropriate animal model, the development of DV therapeutics has been a primary focus of research groups around the world. In the past decade advances in both the development of vaccines and anti-virals have increased in dramatically. This review summarises the current understanding of viral, vector and host factors which contribute to dengue virus pathogenesis and how this knowledge is critically important in the development of pharmaceutical interventions.
dc.publisher.placeUnited States
dc.relation.ispartofjournalPharmacology and Therapeutics
dc.subject.fieldofresearchMedical Virology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.titleDengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.hasfulltextNo Full Text
gro.griffith.authorWolf, Stefan
gro.griffith.authorMahalingam, Suresh
gro.griffith.authorBettadapura, Jayaram
gro.griffith.authorHerrero, Lara J.
gro.griffith.authorChen, Javier
gro.griffith.authorObeysekera, Maheshi P.
gro.griffith.authorSheng, Kuo-Ching
gro.griffith.authorTaylor, Adam
gro.griffith.authorHerring, Belinda

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