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dc.contributor.authorGrkovic, Tanja
dc.contributor.authorCropp, Brent R.
dc.date.accessioned2017-05-03T15:59:44Z
dc.date.available2017-05-03T15:59:44Z
dc.date.issued2013
dc.date.modified2014-01-15T21:54:17Z
dc.identifier.issn1934578X
dc.identifier.urihttp://hdl.handle.net/10072/55638
dc.description.abstractAn embryo development assay using the common New Zealand intertidal species Fellaster zelandiae (sand dollar) is presented. The assay was validated by comparing activity profiles of a range of discorhabdin alkaloids, natural products sourced from Latrunculia spp. sponges containing a core pyrido[2,3- h]pyrrolo[4,3,2-de]quinoline tetracyclic skeleton bound to various spiro-substituents at the C-6 position. Structural features on the discorhabdin molecule that correlated to the greatest degree of F. zelandiae embryo developmental inhibition were the presence of a spiro-dienone moiety and a C-2 bromine substituent. Based on the sand dollar embryo development assay results, a mechanism for the activity of the discorhabdin alkaloids is proposed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1039649 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherNatural Product
dc.publisher.placeUnited States
dc.publisher.urihttp://www.naturalproduct.us/index.asp
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom699
dc.relation.ispartofpageto700
dc.relation.ispartofissue6
dc.relation.ispartofjournalNatural Product Communications
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchBiologically Active Molecules
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchEcology
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchcode030401
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode0602
dc.subject.fieldofresearchcode0607
dc.titleEstablishment of a Phenotypic-based Sand Dollar Fellaster zelandiae Embryo Development Assay and its Application in Defining the Structure-Activity Relationship of Discorhabdin Alkaloids
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2013 Natural Product. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorGrkovic, Tanja


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