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dc.contributor.authorSimmonds, Michael J
dc.contributor.authorConnes, Philippe
dc.contributor.authorSabapathy, Surendran
dc.date.accessioned2017-05-03T13:17:47Z
dc.date.available2017-05-03T13:17:47Z
dc.date.issued2013
dc.date.modified2014-01-17T04:23:46Z
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0071219
dc.identifier.urihttp://hdl.handle.net/10072/55760
dc.description.abstractBackground The effect of exercise-induced lactate production on red blood cell deformability and other blood rheological changes is controversial, given heavy-exercise induces biochemical processes (e.g., oxidative stress) known to perturb haemorheology. The aim of the present study was to examine the haemorheological response to a short-duration cycling protocol designed to increase blood lactate concentration, but of duration insufficient to induce significant oxidative stress. Methods Male cyclists and triathletes (n = 6; 27ᷠyr; body mass index: 23.7ᳮ0 kg/m2; peak oxygen uptake 4.02ᰮ51 L/min) performed unloaded (0 W), moderate-intensity, and heavy-intensity cycling. Blood was sampled at rest and during the final minute of each cycling bout. Blood chemistry, blood viscosity, red blood cell aggregation and red blood cell deformability were measured. Results Blood lactate concentration increased significantly during heavy-intensity cycling, when compared with all other conditions. Methaemoglobin fraction did not change during any exercise bout when compared with rest. Blood viscosity at native haematocrit increased during heavy-intensity cycling at higher-shear rates when compared with rest, unloaded and moderate-intensity cycling. Heavy-intensity exercise increased the amplitude of red blood cell aggregation in native haematocrit samples when compared with all other conditions. Red blood cell deformability was not changed by exercise. Conclusion Acute exercise perturbs haemorheology in an intensity dose-response fashion; however, many of the haemorheological effects appear to be secondary to haemoconcentration, rather than increased lactate concentration.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent332200 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome71219-1
dc.relation.ispartofpagetoe71219-7
dc.relation.ispartofissue8
dc.relation.ispartofjournalPL o S One
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchExercise physiology
dc.subject.fieldofresearchcode420702
dc.titleExercise-Induced Blood Lactate Increase Does Not Change Red Blood Cell Deformability in Cyclists
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://www.plos.org/journals/license.html
gro.rights.copyright© 2013 Simmonds et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CCAL. (http://www.plos.org/journals/license.html)
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorSimmonds, Michael J.


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