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dc.contributor.authorWang, Tao
dc.contributor.authorLin, Zhen
dc.contributor.authorDay, Robert E
dc.contributor.authorGardiner, Bruce
dc.contributor.authorLandao-Bassonga, Euphemie
dc.contributor.authorRubenson, Jonas
dc.contributor.authorKirk, Thomas B
dc.contributor.authorSmith, David W
dc.contributor.authorLloyd, David G
dc.contributor.authorHardisty, Gerard
dc.contributor.authorWang, Allan
dc.contributor.authorZheng, Qiujian
dc.contributor.authorZheng, Ming H
dc.date.accessioned2017-05-03T15:57:18Z
dc.date.available2017-05-03T15:57:18Z
dc.date.issued2013
dc.date.modified2014-01-20T04:09:18Z
dc.identifier.issn0006-3592
dc.identifier.doi10.1002/bit.24809
dc.identifier.urihttp://hdl.handle.net/10072/55830
dc.description.abstractIdentification of functional programmable mechanical stimulation (PMS) on tendon not only provides the insight of the tendon homeostasis under physical/pathological condition, but also guides a better engineering strategy for tendon regeneration. The aims of the study are to design a bioreactor system with PMS to mimic the in vivo loading conditions, and to define the impact of different cyclic tensile strain on tendon. Rabbit Achilles tendons were loaded in the bioreactor with/without cyclic tensile loading (0.25?Hz for 8?h/day, 0-9% for 6 days). Tendons without loading lost its structure integrity as evidenced by disorientated collagen fiber, increased type III collagen expression, and increased cell apoptosis. Tendons with 3% of cyclic tensile loading had moderate matrix deterioration and elevated expression levels of MMP-1, 3, and 12, whilst exceeded loading regime of 9% caused massive rupture of collagen bundle. However, 6% of cyclic tensile strain was able to maintain the structural integrity and cellular function. Our data indicated that an optimal PMS is required to maintain the tendon homeostasis and there is only a narrow range of tensile strain that can induce the anabolic action. The clinical impact of this study is that optimized eccentric training program is needed to achieve maximum beneficial effects on chronic tendinopathy management. Biotechnol. Bioeng.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1495
dc.relation.ispartofpageto1507
dc.relation.ispartofissue5
dc.relation.ispartofjournalBiotechnology and Bioengineering
dc.relation.ispartofvolume110
dc.rights.retentionY
dc.subject.fieldofresearchBiomechanical engineering
dc.subject.fieldofresearchcode400303
dc.titleProgrammable mechanical stimulation influences tendon homeostasis in a bioreactor system
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorLloyd, David


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