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dc.contributor.authorFord, AH
dc.contributor.authorDuncan, GW
dc.contributor.authorFirbank, MJ
dc.contributor.authorYarnall, AJ
dc.contributor.authorKhoo, TK
dc.contributor.authorBurn, DJ
dc.contributor.authorO'Brien, JT
dc.date.accessioned2017-05-03T16:03:22Z
dc.date.available2017-05-03T16:03:22Z
dc.date.issued2013
dc.date.modified2014-01-20T04:44:19Z
dc.identifier.issn0885-3185
dc.identifier.doi10.1002/mds.25367
dc.identifier.urihttp://hdl.handle.net/10072/55872
dc.description.abstractBackground: Rapid eye movement sleep behavior disorder has poor prognostic implications for Parkinson's disease. The authors recruited 124 patients with early Parkinson's disease to compare clinical and neuroimaging findings based on the presence of this sleep disorder. Methods: The presence of rapid eye movement sleep behavior disorder was assessed with the Mayo Sleep Questionnaire. Magnetic resonance imaging sequences were obtained for voxel-based morphometry and diffusion tensor imaging. Results: Patients with sleep disorder had more advanced disease, but groups had similar clinical characteristics and cognitive performance. Those with sleep disorder had areas of reduced cortical grey matter volume and white matter changes compared with those who did not have sleep disorder. However, differences were slight and were not significant when the analyses were adjusted for multiple comparisons. Conclusions: Rapid eye movement sleep behavior disorder was associated with subtle changes in white matter integrity and grey matter volume in patients with early Parkinson's disease.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom832
dc.relation.ispartofpageto836
dc.relation.ispartofissue6
dc.relation.ispartofjournalMovement Disorders
dc.relation.ispartofvolume28
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3209
dc.titleRapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease: Magnetic Resonance Imaging Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorKhoo, Tien Kheng


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