Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas
Author(s)
Lounnas, Nadia
Rosilio, Celia
Nebout, Marielle
Mary, Didier
Griessinger, Emmanuel
Neffati, Zouhour
Chiche, Johanna
Spits, Hergen
Hagenbeek, Thijs J
Asnafi, Vahid
Poulsen, Sally-Ann
Supuran, Claudiu T
Peyron, Jean-Francois
Imbert, Veronique
Griffith University Author(s)
Year published
2013
Metadata
Show full item recordAbstract
The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we obsd. for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacol. inhibition decreased cell proliferation and induced apoptosis. The same results were obsd. with the SupT1 human T cell lymphoma line. In addn. we obsd. an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent ...
View more >The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we obsd. for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacol. inhibition decreased cell proliferation and induced apoptosis. The same results were obsd. with the SupT1 human T cell lymphoma line. In addn. we obsd. an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL.
View less >
View more >The membrane-bound carbonic anhydrase isoforms CAIX and CAXII, underpin a pH-regulating system that enables hypoxic tumor cell survival. Here, we obsd. for the first time an upregulation of CAXII in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LL) cells. First we showed that CAXII is overexpressed in thymocytes from tPTEN-/- mice suffering of T lymphoma and that its pharmacol. inhibition decreased cell proliferation and induced apoptosis. The same results were obsd. with the SupT1 human T cell lymphoma line. In addn. we obsd. an upregulation of CAXII in human T-ALL samples supporting the case that CAXII may represent a new therapeutic target for T-ALL/LL.
View less >
Journal Title
Cancer Letters
Volume
333
Issue
1
Subject
Biologically active molecules
Oncology and carcinogenesis