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dc.contributor.authorAyoobi, Fatemeh
dc.contributor.authorHassanshahi, Gholamhossein
dc.contributor.authorZainodini, Nahid
dc.contributor.authorKhorramdelazad, Hossein
dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-05-03T11:12:38Z
dc.date.available2017-05-03T11:12:38Z
dc.date.issued2013
dc.date.modified2014-01-22T23:10:17Z
dc.identifier.issn2210-7401
dc.identifier.doi10.1016/j.clinre.2012.11.005
dc.identifier.urihttp://hdl.handle.net/10072/55952
dc.description.abstractBackground and aims: TRIF is one of the main intracellular adaptor proteins required for TLR3 and 4 signaling. Abnormal gene expression of TRIF may lead to abrogated immune responses against viral infections including hepatitis B infection. The aim of this study was to identify the mRNA levels of TRIF in PBMCs isolated from chronic HBV (CHB) infected patients. Material and methods: mRNA was isolated from 63 CHB patients and 60 healthy controls and transcript levels of TRIF were examined in parallel with beta-actin (as housekeeping gene) using Real-Time PCR techniques. Results: Our results demonstrated that expression of TRIF was significantly decreased in PBMCs isolated from CHB patients when compared to healthy controls. Conclusions: Based on the results reported here, it seems that CHB patients are unable to express appropriate levels of the TRIF gene, which may attenuate TLR3 and 4 signaling subsequent to HBV infection. Our results suggest a possible mechanism, which may explain why hepatitis B infection is stable in CHB patients.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherElsevier Masson
dc.publisher.placeFrance
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom491
dc.relation.ispartofpageto495
dc.relation.ispartofissue5
dc.relation.ispartofjournalClinics and Research in Hepatology and Gastroenterology
dc.relation.ispartofvolume37
dc.rights.retentionY
dc.subject.fieldofresearchMedical Virology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110804
dc.subject.fieldofresearchcode1103
dc.titleReduced expression of TRIF in chronic HBV infected Iranian patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


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