• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • A prospective study examining the onset and progression of acute toxicity and patient-reported side effects during altered fractionation radiotherapy with concomitant boost for oropharyngeal cancer

    Thumbnail
    View/Open
    88731_1.pdf (928.6Kb)
    Author(s)
    Cartmill, Bena
    Cornwell, Petrea
    Ward, Elizabeth
    Davidson, Wendy
    Porceddu, Sandro
    Griffith University Author(s)
    Cornwell, Petrea
    Year published
    2013
    Metadata
    Show full item record
    Abstract
    Introduction Acute grade 3 and 4 toxicity is commonly reported in trials examining altered fractionation radiotherapy (AFRT), due to its impact on treatment tolerance, the potential for consequential late effects, and mortality. Less well described is the mild-moderate acute toxicity and its impact on function. This study aims to examine acute toxicity and patient-reported side effects, and how they impact on function during AFRT. Study Design A prospective cohort design study. Materials and Methods Thirteen patients with T1-T3 oropharyngeal SCC were assessed weekly during, and at four weeks post-AFRT. Acute toxicity was ...
    View more >
    Introduction Acute grade 3 and 4 toxicity is commonly reported in trials examining altered fractionation radiotherapy (AFRT), due to its impact on treatment tolerance, the potential for consequential late effects, and mortality. Less well described is the mild-moderate acute toxicity and its impact on function. This study aims to examine acute toxicity and patient-reported side effects, and how they impact on function during AFRT. Study Design A prospective cohort design study. Materials and Methods Thirteen patients with T1-T3 oropharyngeal SCC were assessed weekly during, and at four weeks post-AFRT. Acute toxicity was graded using the CTCAE, and patients attended speech pathology/dietetic reviews where they reported functional barriers. Swallowing and weight measures were recorded. Results Most participants experienced peak grade 2 toxicity for all CTCAE components, except laryngeal edema. Grade 3 mucositis and dysphagia was noted in 31% and 23% respectively. Peak toxicity occurred in week 5 of treatment; however barriers to oral intake occurred from week 1. Modified diet with supplementation was required for 92% by week 3. Participants lost 5 kg during treatment. By four weeks post-treatment acute toxicity was resolving, with ongoing diet modification and weight loss. Conclusion Mild-moderate acute toxicity impacted on functional swallowing and weight from weeks 1-2, with increasing severity by week 3, before patients commenced their twice daily "concomitant boost" treatments. As acute toxicity resolved, the impact on oral intake and weight continued. Future studies should record toxicity and barriers to oral intake routinely until its resolution, rather than at arbitrary time points post-treatment.
    View less >
    Journal Title
    World Journal of Surgical Medical and Radiation Oncology
    Volume
    2
    Publisher URI
    http://www.npplweb.com/wjsmro/content/2/6
    Copyright Statement
    © The Author(s) 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Medical and Health Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/55982
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander