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  • Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment

    Author(s)
    Rohlena, Jakub
    Dong, Lan-feng
    Neuzil, Jiri
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2013
    Metadata
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    Abstract
    Treatment of cancer is by no means universally successful and often manifests harmful side effects. The best way to improve the success rate and reduce the side effects would be to develop compounds that are able to kill cancer cells while leaving normal cells unaffected. In this respect, mitocans (an acronym from 'mitochondria' and 'cancer'), a summary term we proposed for compounds that induce cell death by targeting mitochondria, show an encouraging trend. Here we provide an overview of mitocans specific for the mitochondrial electron transport chain. These mitocans are particularly interesting, because a frequent consequence ...
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    Treatment of cancer is by no means universally successful and often manifests harmful side effects. The best way to improve the success rate and reduce the side effects would be to develop compounds that are able to kill cancer cells while leaving normal cells unaffected. In this respect, mitocans (an acronym from 'mitochondria' and 'cancer'), a summary term we proposed for compounds that induce cell death by targeting mitochondria, show an encouraging trend. Here we provide an overview of mitocans specific for the mitochondrial electron transport chain. These mitocans are particularly interesting, because a frequent consequence of electron transport chain inhibition is the induction of superoxide formation resulting in the preferential killing of cancer cells, as these tend to be more sensitive than normal cells to sudden increases in oxidative stress. Furthermore, macromolecular complexes of the electron transport chain only rarely mutate in cancer, and represent useful targets for anti-cancer drug development when widely-applicable agents are sought.
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    Journal Title
    Current Pharmaceutical Biotechnology
    Volume
    14
    Issue
    3
    DOI
    https://doi.org/10.2174/1389201011314030011
    Subject
    Medical biotechnology
    Cancer cell biology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/56010
    Collection
    • Journal articles

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