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  • A genome-wide analysis of annexins from parasitic organisms and their vectors

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    Author(s)
    Cantacessi, Cinzia
    Seddon, Jennifer M
    Miller, Terrence L
    Leow, Chiuan Yee
    Thomas, Laetitia
    Mason, Lyndel
    Willis, Charlene
    Walker, Giselle
    Loukas, Alex
    Gasser, Robin B
    Jones, Malcolm K
    Hofmann, Andreas
    Griffith University Author(s)
    Hofmann, Andreas
    Willis, Charlene
    Mason, Lyndel
    Thomas, Laetitia
    Jones, Malcolm K.
    Year published
    2013
    Metadata
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    Abstract
    In this study, we conduct an in-depth analysis of annexin proteins from a diverse range of invertebrate taxa, including the major groups that contain the parasites and vector organisms that are harmful to humans and domestic animals. Using structure-based amino acid sequence alignments and phylogenetic analyses, we present a classification for this protein group and assign names to sequences with ambiguous annotations in public databases. Our analyses reveal six distinct annexin clades, and the mapping of genes encoding annexins to the genome of the human blood fluke Schistosoma mansoni supports the hypothesis of gene ...
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    In this study, we conduct an in-depth analysis of annexin proteins from a diverse range of invertebrate taxa, including the major groups that contain the parasites and vector organisms that are harmful to humans and domestic animals. Using structure-based amino acid sequence alignments and phylogenetic analyses, we present a classification for this protein group and assign names to sequences with ambiguous annotations in public databases. Our analyses reveal six distinct annexin clades, and the mapping of genes encoding annexins to the genome of the human blood fluke Schistosoma mansoni supports the hypothesis of gene duplication as a major evolutionary event in annexin genesis. This study illuminates annexin diversity from a novel perspective using contemporary phylogenetic hypotheses of eukaryote evolution, and will aid the consolidation of annexin protein identities in public databases and provide a foundation for future functional analysis and characterisation of these proteins in parasites of socioeconomic importance.
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    Journal Title
    Scientific Reports
    Volume
    3
    DOI
    https://doi.org/10.1038/srep02893
    Copyright Statement
    © 2013 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Medical parasitology
    Publication URI
    http://hdl.handle.net/10072/56064
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    • Journal articles

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