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  • Mitochondrial complex II, a novel target for anti-cancer agents

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    KluckovaPUB32.pdf (566.9Kb)
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    Accepted Manuscript (AM)
    Author(s)
    Kluckova, Katarina
    Bezawork-Geleta, Ayanachew
    Rohlena, Jakub
    Dong, Lanfeng
    Neuzil, Jiri
    Griffith University Author(s)
    Neuzil, Jiri
    Dong, Lan-feng
    Bezawork-Geleta, Ayenachew
    Rohlena, Jakub
    Year published
    2013
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    Abstract
    With the arrival of the third millennium, in spite of unprecedented progress in molecular medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the potential response of cancer cells to anti-cancer agents, has been recently highlighted in a landmark paper by Weinberg and Hanahan on hallmarks of cancer [1]. Together with the recently published papers on the complexity of tumours in patients and even within the same tumour (see below), the cure for this pathology seems to be an elusive goal. Indisputably, the strategy ought to be changed, searching for targets that are generally invariant across the ...
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    With the arrival of the third millennium, in spite of unprecedented progress in molecular medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the potential response of cancer cells to anti-cancer agents, has been recently highlighted in a landmark paper by Weinberg and Hanahan on hallmarks of cancer [1]. Together with the recently published papers on the complexity of tumours in patients and even within the same tumour (see below), the cure for this pathology seems to be an elusive goal. Indisputably, the strategy ought to be changed, searching for targets that are generally invariant across the landscape of neoplastic diseases. One such target appears to be the mitochondrial complex II (CII) of the electron transfer chain, a recent focus of research. We document and highlight this particularly intriguing target in this review paper and give examples of drugs that use CII as their molecular target. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.
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    Journal Title
    Biochimica et Biophysica Acta
    Volume
    1827
    Issue
    5
    DOI
    https://doi.org/10.1016/j.bbabio.2012.10.015
    Copyright Statement
    © 2003 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Physical chemistry
    Biochemistry and cell biology
    Cancer cell biology
    Publication URI
    http://hdl.handle.net/10072/56094
    Collection
    • Journal articles

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