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dc.contributor.authorKluckova, Katarina
dc.contributor.authorBezawork-Geleta, Ayanachew
dc.contributor.authorRohlena, Jakub
dc.contributor.authorDong, Lanfeng
dc.contributor.authorNeuzil, Jiri
dc.date.accessioned2017-09-07T01:26:44Z
dc.date.available2017-09-07T01:26:44Z
dc.date.issued2013
dc.date.modified2014-01-23T23:05:33Z
dc.identifier.issn0005-2728
dc.identifier.doi10.1016/j.bbabio.2012.10.015
dc.identifier.urihttp://hdl.handle.net/10072/56094
dc.description.abstractWith the arrival of the third millennium, in spite of unprecedented progress in molecular medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the potential response of cancer cells to anti-cancer agents, has been recently highlighted in a landmark paper by Weinberg and Hanahan on hallmarks of cancer [1]. Together with the recently published papers on the complexity of tumours in patients and even within the same tumour (see below), the cure for this pathology seems to be an elusive goal. Indisputably, the strategy ought to be changed, searching for targets that are generally invariant across the landscape of neoplastic diseases. One such target appears to be the mitochondrial complex II (CII) of the electron transfer chain, a recent focus of research. We document and highlight this particularly intriguing target in this review paper and give examples of drugs that use CII as their molecular target. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom552
dc.relation.ispartofpageto564
dc.relation.ispartofissue5
dc.relation.ispartofjournalBiochimica et Biophysica Acta
dc.relation.ispartofvolume1827
dc.rights.retentionY
dc.subject.fieldofresearchPhysical chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchCancer cell biology
dc.subject.fieldofresearchcode3406
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode321101
dc.titleMitochondrial complex II, a novel target for anti-cancer agents
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2003 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorDong, Lan-feng
gro.griffith.authorBezawork-Geleta, Ayenachew
gro.griffith.authorRohlena, Jakub


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