dc.contributor.author | Weetman, J | |
dc.contributor.author | Wong, MB | |
dc.contributor.author | Sharry, S | |
dc.contributor.author | Rcom-H'cheo-Gauthier, A | |
dc.contributor.author | Gai, WP | |
dc.contributor.author | Meedeniya, A | |
dc.contributor.author | Pountney, DL | |
dc.date.accessioned | 2017-05-03T15:06:19Z | |
dc.date.available | 2017-05-03T15:06:19Z | |
dc.date.issued | 2013 | |
dc.date.modified | 2014-01-29T22:38:43Z | |
dc.identifier.issn | 0304-3940 | |
dc.identifier.doi | 10.1016/j.neulet.2013.03.057 | |
dc.identifier.uri | http://hdl.handle.net/10072/56105 | |
dc.description.abstract | Parkinson's disease (PD) is a neurodegenerative disease resulting from progressive loss of dopaminergic nigrostriatal neurons. _-Synuclein protein conformational changes, resulting in cytotoxic/aggregated proteins, have been linked to PD pathogenesis. We investigated a unilateral rotenone-lesioned mouse PD model. Unilateral lesion of the medial forebrain bundle for two groups of male C57 black mice (n = 5); adult (6-12 months) group and aged (1.75-2 years) group, was via stereotactic rotenone injection. After 2 weeks post-lesion, phenotypic Parkinsonian symptoms, resting tremor, postural instability, left-handed bias, ipsiversive rotation and bradykinesia were observed and were more severe in the aged group. We investigated protein expression profiles of the post-translational modifier, SUMO-1, and _-synuclein between the treated and control hemisphere, and between adult and aged groups. Western analysis of the brain homogenates indicated that there were statistically significant (p < 0.05) increases in several specific molecular weight species (ranging 12-190 kDa) of both SUMO-1 (0.75-4.3-fold increased) and _-synuclein (1.6-19-fold increase) in the lesioned compared to un-lesioned hemisphere, with the adult mice showing proportionately greater increases in SUMO-1 than the aged group. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Ireland | |
dc.relation.ispartofstudentpublication | Y | |
dc.relation.ispartofpagefrom | 119 | |
dc.relation.ispartofpageto | 124 | |
dc.relation.ispartofjournal | Neuroscience Letters | |
dc.relation.ispartofvolume | 544 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Central nervous system | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.fieldofresearchcode | 320903 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.title | Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.date.issued | 2013 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Pountney, Dean L. | |