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dc.contributor.authorWeetman, J
dc.contributor.authorWong, MB
dc.contributor.authorSharry, S
dc.contributor.authorRcom-H'cheo-Gauthier, A
dc.contributor.authorGai, WP
dc.contributor.authorMeedeniya, A
dc.contributor.authorPountney, DL
dc.date.accessioned2017-05-03T15:06:19Z
dc.date.available2017-05-03T15:06:19Z
dc.date.issued2013
dc.date.modified2014-01-29T22:38:43Z
dc.identifier.issn0304-3940
dc.identifier.doi10.1016/j.neulet.2013.03.057
dc.identifier.urihttp://hdl.handle.net/10072/56105
dc.description.abstractParkinson's disease (PD) is a neurodegenerative disease resulting from progressive loss of dopaminergic nigrostriatal neurons. _-Synuclein protein conformational changes, resulting in cytotoxic/aggregated proteins, have been linked to PD pathogenesis. We investigated a unilateral rotenone-lesioned mouse PD model. Unilateral lesion of the medial forebrain bundle for two groups of male C57 black mice (n = 5); adult (6-12 months) group and aged (1.75-2 years) group, was via stereotactic rotenone injection. After 2 weeks post-lesion, phenotypic Parkinsonian symptoms, resting tremor, postural instability, left-handed bias, ipsiversive rotation and bradykinesia were observed and were more severe in the aged group. We investigated protein expression profiles of the post-translational modifier, SUMO-1, and _-synuclein between the treated and control hemisphere, and between adult and aged groups. Western analysis of the brain homogenates indicated that there were statistically significant (p < 0.05) increases in several specific molecular weight species (ranging 12-190 kDa) of both SUMO-1 (0.75-4.3-fold increased) and _-synuclein (1.6-19-fold increase) in the lesioned compared to un-lesioned hemisphere, with the adult mice showing proportionately greater increases in SUMO-1 than the aged group.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom119
dc.relation.ispartofpageto124
dc.relation.ispartofjournalNeuroscience Letters
dc.relation.ispartofvolume544
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCentral nervous system
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320903
dc.subject.fieldofresearchcode5204
dc.titleIncreased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorPountney, Dean L.


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