NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Thumbnail
View/Open
File version
Accepted Manuscript (AM)
Author(s)
Wedlock, Louise E
Kilburn, Matt R
Liu, Rong
Shaw, Jeremy A
Berners-Price, Susan J
Farrell, Nicholas P
Griffith University Author(s)
Year published
2013
Metadata
Show full item record
Abstract
Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.
Journal Title
Chemical Communications
Volume
49
Issue
62
DOI
Funder(s)
ARC
Grant identifier(s)
DP1095383
Copyright Statement
© 2013 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
Subject
Chemical sciences
Bioinorganic chemistry
Publication URI
Collection