Front-Loading Natural-Product-Screening Libraries for log P: Background, Development, and Implementation
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In the period from January 1981 to December 2010, 1068 small-molecule new chemical entities (NCEs) were introduced, of which ca. 34% are either a natural product or a close analogue. While this metric reflects the impact natural products have played in delivering new chemical starting points (leads) for the pharmaceutical industry, it does not capture the decline this approach has suffered over the last 20 years as the high-throughput screening (HTS) of pure compound libraries has become more popular. An impediment to natural-product drug discovery in the HTS paradigm is the lack of a clear strategy that enables front-loading of an extract or fraction's chemical constituents so that they are compliant with lead- and drug-like chemical space. To address this imbalance, an approach based on lipophilicity, as measured by clog P has been developed that, together with advances being made in isolation and structural elucidation, can afford natural product leads in timelines compatible with pure compound screening.
Chemistry & Biodiversity
Copyright 2013 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland. This is the author-manuscript version of the following article: Front-Loading Natural-Product-Screening Libraries for log P: Background, Development, and Implementation, Chemistry & Biodiversity, Volume 10, Issue 4, pages 524–537, April 2013, which has been published in final form at http://dx.doi.org/10.1002/cbdv.201200302
Medicinal and Biomolecular Chemistry not elsewhere classified