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dc.contributor.authorKularatna, Sanjeewa
dc.contributor.authorWhitty, Jennifer A
dc.contributor.authorJohnson, Newell W
dc.contributor.authorScuffham, Paul A
dc.date.accessioned2017-05-03T14:21:09Z
dc.date.available2017-05-03T14:21:09Z
dc.date.issued2013
dc.date.modified2014-01-31T03:36:55Z
dc.identifier.issn1477-7525
dc.identifier.doi10.1186/1477-7525-11-149
dc.identifier.urihttp://hdl.handle.net/10072/56300
dc.description.abstractBackground Economic evaluations to inform decisions about allocation of health resources are scarce in Low and Middle Income Countries, including in Sri Lanka. This is in part due to a lack of country-specific utility weights, which are necessary to derive appropriate Quality Adjusted Life Years. The EQ-5D-3L, a generic multi-attribute instrument (MAUI), is most widely used to measure and value health states in high income countries; nevertheless, the sensitivity of generic MAUIs has been criticised in some conditions such as cancer. This article describes a protocol to produce both a generic EQ-5D-3L and cancer specific EORTC-8D utility index in Sri Lanka. Method EQ-5D-3L and EORTC-8D health states will be valued using the Time Trade-Off technique, by a representative population sample (n?=?780 invited) identified using stratified multi-stage cluster sampling with probability proportionate to size method. Households will be randomly selected within 30 clusters across four districts; one adult (=18 years) within each household will be selected using the Kish grid method. Data will be collected via face-to-face interview, with a Time Trade-Off board employed as a visual aid. Of the 243 EQ-5D-3L and 81,290 EORTC-8D health states, 196 and 84 respectively will be directly valued. In EQ-5D-3L, all health states that combine level 3 on mobility with either level 1 on usual activities or self-care were excluded. Each participant will first complete the EQ-5D-3L, rank and value 14 EQ-5D-3L states (plus the worst health state and "immediate death"), and then rank and value seven EORTC-8D states (plus "immediate death"). Participant demographic and health characteristics will be also collected. Regression models will be fitted to estimate utility indices for EQ-5D-3L and EORTC-8D health states for Sri Lanka. The dependent variable will be the utility value. Different specifications of independent variables will be derived from the ordinal EQ-5D-3L to test for the best-fitting model. Discussion In Sri Lanka, a LMIC health state valuation will have to be carried out using face to face interview instead of online methods. The proposed study will provide the first country-specific health state valuations for Sri Lanka, and one of the first valuations to be completed in a South Asian Country.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent196639 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom149-1
dc.relation.ispartofpageto149-8
dc.relation.ispartofjournalHealth and Quality of Life Outcomes
dc.relation.ispartofvolume11
dc.rights.retentionY
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.titleStudy protocol for valuing EQ-5D-3L and EORTC-8D health states in a representative population sample in Sri Lanka
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.facultyGriffith Health, School of Medicine
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 149.
gro.rights.copyright© 2013 Kularatna et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorJohnson, Newell W.
gro.griffith.authorScuffham, Paul A.


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