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dc.contributor.authorKockler, Jutta
dc.contributor.authorRobertson, Sherryl
dc.contributor.authorHope, Denise
dc.contributor.authorHaywood, Alison
dc.contributor.authorGlass, Beverley
dc.contributor.editorDr Christopher Alderman
dc.date.accessioned2017-10-11T12:30:43Z
dc.date.available2017-10-11T12:30:43Z
dc.date.issued2013
dc.date.modified2014-02-03T04:03:24Z
dc.identifier.issn1445-937X
dc.identifier.urihttp://hdl.handle.net/10072/56356
dc.description.abstractBackground: Paracetamol tablets are often repackaged into dose administration aids (DAAs) for prn use. Pharmacists have limited information regarding the long-term stability of prn medicines stored in DAAs for extended periods due to infrequent dosing. According to current guidelines, in the absence of specific data, medicines should not be stored in a DAA for longer than 8 weeks. Aim: To determine the physicochemical stability of paracetamol tablets repackaged into DAAs and stored for 12 months. Method: Paracetamol (Panamax) tablets were removed from primary packaging, repackaged into DAAs (Multi Dose Webster-pak) and stored under ambient (25 ꃻ 60% relative humidity) and accelerated (40 ꃻ 75% relative humidity) conditions for 12 months. Physical characteristics of the tablets, such as appearance, weight uniformity, thickness, hardness, friability, disintegration and dissolution rates were evaluated at baseline, 3, 6 and 12 months. Chemical stability was confirmed by high performance liquid chromatography. Results: All compendial requirements for physical stability were met for tablets stored under ambient and accelerated conditions over the 12-month period. Chemical stability was confirmed, with paracetamol content in the tablets within the British Pharmacopoeial range of 95% to 105% of the labelled amount. Conclusion: This study provides data on the stability of paracetamol tablets repackaged into DAAs and stored under ambient and accelerated conditions for 12 months. Pharmacists will be able to make risk-benefit assessments and recommend a 12-month expiry on paracetamol prn DAAs.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent394342 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherSociety of Hospital Pharmacists of Australia
dc.publisher.placeAustralia
dc.publisher.urihttp://jppr.shpa.org.au
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom218
dc.relation.ispartofpageto220
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Pharmacy Practice and Research
dc.relation.ispartofvolume43
dc.rights.retentionY
dc.subject.fieldofresearchPharmaceutical Sciences
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode111504
dc.subject.fieldofresearchcode1115
dc.titleStability of paracetamol tablets repackaged in dose administration aids for prn use: Implications for practice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2013 Journal of Pharmacy Practice and Research. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorHaywood, Alison
gro.griffith.authorHope, Denise


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