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dc.contributor.authorVaughan, Tanya
dc.contributor.authorM. Reid, David
dc.contributor.authorMorrison, Nigel
dc.contributor.authorH. Ralston, Stuart
dc.date.accessioned2017-05-03T11:03:10Z
dc.date.available2017-05-03T11:03:10Z
dc.date.issued2004
dc.date.modified2007-03-18T21:35:59Z
dc.identifier.issn87563282
dc.identifier.urihttp://hdl.handle.net/10072/5639
dc.description.abstractBone mineral density (BMD) is influenced by both environmental and genetic factors. We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. We genotyped 991 women from a Scottish cohort to decipher the role of RUNX2 alleles in regulating BMD. The alleles of RUNX2 within the glutamine-alanine repeat were determined by MspA1I restriction digest. Allele frequencies estimated from Scottish cohort were G allele, 0.87 ᠰ.01; A allele, 0.08 ᠰ.01; and 11Ala alanine deletion allele, 0.05 ᠰ.01. Analysis of covariance (ANCOVA) was used to adjust for the covariates weight and age for BMD at the femoral neck (FN). The A allele was associated with higher FN BMD (P = 0.035) within a postmenopausal subgroup of the population (n = 312). The effect of RUNX2 A alleles increased with increasing weight; A alleles were associated with FN BMD in those above the median BMI (BMI > 25), while no association was observed in thin/normal (BMI = 25) postmenopausal women. Glutamine variants and an alanine insertion were identified within the group. These data suggest that the RUNX2 alleles are associated with BMD in a menopause- and weight-dependent manner.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeInternational
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/525233/description#description
dc.relation.ispartofpagefrom1029
dc.relation.ispartofpageto1036
dc.relation.ispartofjournalBone
dc.relation.ispartofvolume34
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode09
dc.subject.fieldofresearchcode11
dc.titleRUNX2 alleles associated with BMD in Scottish women; interaction of RUNX2 alleles with menopausal status and body mass index.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorMorrison, Nigel A.
gro.griffith.authorVaughan, Tanya


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