Association of a Polymorphism Within Intron 8 But Not Exon 9 of the Vitamin D Receptor in Patients With Multiple Sclerosis of Southeastern Iranian Ethnicity
Author(s)
Mosavi, Reza
Arababadi, Mohammad Kazemi
Hassanshahi, Gholamhossein
Azin, Hossein
Araste, Majid
Salehabad, Vajihe Akbarpour
Vazirinejad, Reza
Pourali, Reza
Hakimi, Hamid
Kennedy, Derek
Griffith University Author(s)
Year published
2013
Metadata
Show full item recordAbstract
Objective: To investigate the association between multiple sclerosis (MS) and polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) gene. Methods: Blood samples were collected from 100 patients with MS and 100 healthy control individuals in ethylenediaminetetraacetic acid (EDTA) tubes. DNA was extracted and analyzed via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for polymorphisms within the VDR. Demographic data were also collected via a questionnaire designed specifically for this study. Results: Our results showed a significant difference between the A/A genotype and ...
View more >Objective: To investigate the association between multiple sclerosis (MS) and polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) gene. Methods: Blood samples were collected from 100 patients with MS and 100 healthy control individuals in ethylenediaminetetraacetic acid (EDTA) tubes. DNA was extracted and analyzed via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for polymorphisms within the VDR. Demographic data were also collected via a questionnaire designed specifically for this study. Results: Our results showed a significant difference between the A/A genotype and between the A and a alleles of intron 8 of VDR; however, no differences were observed in the other studied alleles. Conclusion: VDR and its functional polymorphisms may be associated with MS.
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View more >Objective: To investigate the association between multiple sclerosis (MS) and polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) gene. Methods: Blood samples were collected from 100 patients with MS and 100 healthy control individuals in ethylenediaminetetraacetic acid (EDTA) tubes. DNA was extracted and analyzed via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for polymorphisms within the VDR. Demographic data were also collected via a questionnaire designed specifically for this study. Results: Our results showed a significant difference between the A/A genotype and between the A and a alleles of intron 8 of VDR; however, no differences were observed in the other studied alleles. Conclusion: VDR and its functional polymorphisms may be associated with MS.
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Journal Title
Laboratory Medicine
Volume
44
Issue
3
Publisher URI
Copyright Statement
Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Subject
Neurology and neuromuscular diseases