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dc.contributor.authorNilsen, Aaron
dc.contributor.authorLaCrue, Alexis N
dc.contributor.authorWhite, Karen L
dc.contributor.authorForquer, Isaac P
dc.contributor.authorCross, R Matthew
dc.contributor.authorMarfurt, Jutta
dc.contributor.authorMather, Michael W
dc.contributor.authorDelves, Michael J
dc.contributor.authorShackleford, David M
dc.contributor.authorSaenz, Fabian E
dc.contributor.authorMorrisey, Joanne M
dc.contributor.authorSteuten, Jessica
dc.contributor.authorMutka, Tina
dc.contributor.authorLi, Yuexin
dc.contributor.authorWirjanata, Grennady
dc.contributor.authorRyan, Eileen
dc.contributor.authorDuffy, Sandra
dc.contributor.authorKelly, Jane Xu
dc.contributor.authorSebayang, Boni F
dc.contributor.authorZeeman, Anne-Marie
dc.contributor.authorNoviyanti, Rintis
dc.contributor.authorSinden, Robert E
dc.contributor.authorKocken, Clemens HM
dc.contributor.authorPrice, Ric N
dc.contributor.authorAvery, Vicky M
dc.contributor.authorAngulo-Barturen, Inigo
dc.contributor.authorBelen Jimenez-Diaz, Maria
dc.contributor.authorFerrer, Santiago
dc.contributor.authorHerreros, Esperanza
dc.contributor.authorSanz, Laura M
dc.contributor.authorGamo, Francisco-Javier
dc.contributor.authorBathurst, Ian
dc.contributor.authorBurrows, Jeremy N
dc.contributor.authorSiegl, Peter
dc.contributor.authorGuy, R Kiplin
dc.contributor.authorWinter, Rolf W
dc.contributor.authorVaidya, Akhil B
dc.contributor.authorCharman, Susan A
dc.contributor.authorKyle, Dennis E
dc.contributor.authorManetsch, Roman
dc.contributor.authorRiscoe, Michael K
dc.date.accessioned2018-05-03T01:00:30Z
dc.date.available2018-05-03T01:00:30Z
dc.date.issued2013
dc.date.modified2014-10-07T23:46:44Z
dc.identifier.issn1946-6234
dc.identifier.doi10.1126/scitranslmed.3005029
dc.identifier.urihttp://hdl.handle.net/10072/56606
dc.description.abstractThe goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of the disease. The 4(1H)-quinolone-3-diarylethers are selective potent inhibitors of the parasite's mitochondrial cytochrome bc1 complex. These compounds are highly active against the human malaria parasites Plasmodium falciparum and Plasmodium vivax. They target both the liver and blood stages of the parasite as well as the forms that are crucial for disease transmission, that is, the gametocytes, the zygote, the ookinete, and the oocyst. Selected as a preclinical candidate, ELQ-300 has good oral bioavailability at efficacious doses in mice, is metabolically stable, and is highly active in blocking transmission in rodent models of malaria. Given its predicted low dose in patients and its predicted long half-life, ELQ-300 has potential as a new drug for the treatment, prevention, and, ultimately, eradication of human malaria.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for the Advancement of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom177ra37-129
dc.relation.ispartofpageto177ra37-141
dc.relation.ispartofissue177
dc.relation.ispartofjournalScience Translational Medicine
dc.relation.ispartofvolume5
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode3206
dc.subject.fieldofresearchcode4003
dc.titleQuinolone-3-Diarylethers: a new class of antimalarial drug
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© The Author(s) 2013. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science: Translational Medicine in Vol. 5, Issue 177, pp. 177ra37, 10.1126/scitranslmed.3005029
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


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