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dc.contributor.authorVenardos, K
dc.contributor.authorHarrison, G
dc.contributor.authorHeadrick, J
dc.contributor.authorPerkins, A
dc.contributor.editorVirginia Negretti de Braetter [Editor-in-Chief]
dc.date.accessioned2017-05-03T11:16:56Z
dc.date.available2017-05-03T11:16:56Z
dc.date.issued2004
dc.date.modified2009-09-23T02:35:33Z
dc.identifier.issn0946-672X
dc.identifier.doi10.1016/j.jtemb.2004.01.001
dc.identifier.urihttp://hdl.handle.net/10072/5663
dc.description.abstractGlutathione peroxidase and thioredoxin reductase are selenocysteine-dependent enzymes that protect against oxidative injury. This study examined the effects of dietary selenium on the activity of these two enzymes in rats, and investigated the ability of selenium to modulate myocardial function post ischemia-reperfusion. Male wistar rats were fed diets containing 0, 50, 240 and 1000 姯kg sodium selenite for 5 weeks. Langendorff perfused hearts isolated from these rats were subjected to 22.5 min global ischemia and 45 min reperfusion, with functional recovery assessed. Liver samples were collected at the time of sacrifice, and heart and liver tissues assayed for thioredoxin reductase and glutathione peroxidase activity. Selenium deficiency reduced the activity of both glutathione peroxidase and thioredoxin reductase systemically. Hearts from selenium deficient animals were more susceptible to ischemia-reperfusion injury when compared to normal controls (38% recovery of rate pressure product (RPP) vs. 47% recovery of RPP). Selenium supplementation increased the endogenous activity of thioredoxin reductase and glutathione peroxidase and resulted in improved recovery of cardiac function post ischemia-reperfusion (57% recovery of RPP). Endogenous activity of glutathione peroxidase and thioredoxin reductase is dependent on an adequate supply of the micronutrient selenium. Reduced activity of these antioxidant enzymes is associated with significant reductions in myocardial function post ischemia-reperfusion.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier - Urban und Fischer
dc.publisher.placeGermany
dc.relation.ispartofpagefrom81
dc.relation.ispartofpageto88
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Trace Elements in Medicine and Biology
dc.relation.ispartofvolume18
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3208
dc.titleEffects of dietary selenium on glutathione peroxidase and thioredoxin reductase activity and recovery from cardiac ischemia-reperfusion
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2004 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorHeadrick, John P.
gro.griffith.authorHarrison, Glenn J.


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