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dc.contributor.authorGrealy, Rebecca
dc.contributor.authorSmith, Carl LE
dc.contributor.authorChen, Timothy
dc.contributor.authorHiller, Doug
dc.contributor.authorHaseler, Luke J
dc.contributor.authorGriffiths, Lyn R
dc.date.accessioned2017-05-03T15:01:37Z
dc.date.available2017-05-03T15:01:37Z
dc.date.issued2013
dc.date.modified2014-02-16T23:24:54Z
dc.identifier.issn1440-2440
dc.identifier.doi10.1016/j.jsams.2012.08.013
dc.identifier.urihttp://hdl.handle.net/10072/56805
dc.description.abstractOBJECTIVES: To investigate the frequency of the ACTN3 R577X polymorphism in elite endurance triathletes, and whether ACTN3 R577X is significantly associated with performance time. DESIGN: Cross-sectional study. METHODS: Saliva samples, questionnaires, and performance times were collected for 196 elite endurance athletes who participated in the 2008 Kona Ironman championship triathlon. Athletes were of predominantly North American, European, and Australian origin. A one-way analysis of variance was conducted to compare performance times between genotype groups. Multiple linear regression analysis was performed to model the effect of questionnaire variables and genotype on performance time. Genotype and allele frequencies were compared to results from different populations using the chi-square test. RESULTS: Performance time did not significantly differ between genotype groups, and age, sex, and continent of origin were significant predictors of finishing time (age and sex: p<5ױ0(-6); continent: p=0.003) though genotype was not. Genotype and allele frequencies obtained (RR 26.5%, RX 50.0%, XX 23.5%, R 51.5%, X 48.5%) were found to be not significantly different from Australian, Spanish, and Italian endurance athletes (p>0.05), but were significantly different from Kenyan, Ethiopian, and Finnish endurance athletes (p<0.01). CONCLUSIONS: Genotype and allele frequencies agreed with those reported for endurance athletes of similar ethnic origin, supporting previous findings for an association between 577X allele and endurance. However, analysis of performance time suggests that ACTN3 does not alone influence endurance performance, or may have a complex effect on endurance performance due to a speed/endurance trade-off.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom365
dc.relation.ispartofpageto371
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Science and Medicine in Sport
dc.relation.ispartofvolume16
dc.rights.retentionY
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchSports science and exercise not elsewhere classified
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode420799
dc.subject.fieldofresearchcode3208
dc.titleThe genetics of endurance: Frequency of the ACTN3 R577X variant in Ironman World Championship athletes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.date.issued2013
gro.hasfulltextNo Full Text
gro.griffith.authorHaseler, Luke J.
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorChen, Timothy
gro.griffith.authorGrealy, Rebecca
gro.griffith.authorSmith, Carl LE.


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