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dc.contributor.authorSanthakumar, AB
dc.contributor.authorBulmer, AC
dc.contributor.authorSingh, I
dc.date.accessioned2019-01-04T12:31:07Z
dc.date.available2019-01-04T12:31:07Z
dc.date.issued2014
dc.date.modified2014-02-28T02:33:02Z
dc.identifier.issn0952-3871
dc.identifier.doi10.1111/jhn.12177
dc.identifier.urihttp://hdl.handle.net/10072/56864
dc.description.abstractDietary sources of polyphenols, which are derivatives and/or isomers of flavones, isoflavones, flavonols, catechins and phenolic acids, possess antioxidant properties and therefore might be important in preventing oxidative-stress-induced platelet activation and attenuating adverse haemostatic function. Free radicals, including reactive oxygen and nitrogen species, promote oxidative stress, leading to platelet hyperactivation and the risk of thrombosis. The consumption of antioxidant/polyphenol rich foods might therefore impart anti-thrombotic and cardiovascular protective effects via their inhibition of platelet hyperactivation or aggregation. Most commonly-used anti-platelet drugs such as aspirin block the cyclooxygenase (COX)-1 pathway of platelet activation, similar to the action of antioxidants with respect to neutralising hydrogen peroxide (H2O2), with a similar effect on thromboxane production via the COX-1 pathway. Polyphenols also target various additional platelet activation pathways (e.g. by blocking platelet-ADP, collagen receptors); thus alleviating fibrinogen binding to platelet surface (GPIIb-IIIa) receptors, reducing further platelet recruitment for aggregation and inhibiting platelet degranulation. As a result of the ability of polyphenols to target additional pathways of platelet activation, they may have the potential to substitute or complement currently used anti-platelet drugs in sedentary, obese, pre-diabetic or diabetic populations who can be resistant or sensitive to pharmacological anti-platelet therapy.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1704941 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto21
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Human Nutrition and Dietetics
dc.relation.ispartofvolume27
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchNutrition and dietetics
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3210
dc.subject.fieldofresearchcode3202
dc.titleA review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2013 John Wiley & Sons, Ltd. This is the pre-peer reviewed version of the following article: A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk, Journal of Human Nutrition and Dietetics, Volume 27, Issue 1, 2013, pages 1–21, which has been published in final form at dx.doi.org/10.1111/jhn.12177.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorBulmer, Andrew C.
gro.griffith.authorSingh, Indu


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