Reduced Life Expectancy Model for Effects of Long Term Exposure on Lethal Toxicity with Fish

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Author(s)
Verma, Vibha
Yu, Qiming J
Connell, Des W
Year published
2013
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A model based on the concept of reduction in life expectancy (RLE model) as a result of long term exposure to toxicant has been developedwhich has normal life expectancy (NLT) as a fixed limiting point for a species.Themodel is based on the equation (LC50 = a ln(LT50) + b) where a and b are constants. It was evaluated by plotting ln LT50 against LC50 with data on organic toxicants obtained from the scientific literature. Linear relationships between LC50 and ln LT50 were obtained and a Calculated NLT was derived from the plots. The Calculated NLT obtained was in good agreement with the Reported NLT obtained from the literature. ...
View more >A model based on the concept of reduction in life expectancy (RLE model) as a result of long term exposure to toxicant has been developedwhich has normal life expectancy (NLT) as a fixed limiting point for a species.Themodel is based on the equation (LC50 = a ln(LT50) + b) where a and b are constants. It was evaluated by plotting ln LT50 against LC50 with data on organic toxicants obtained from the scientific literature. Linear relationships between LC50 and ln LT50 were obtained and a Calculated NLT was derived from the plots. The Calculated NLT obtained was in good agreement with the Reported NLT obtained from the literature. Estimation of toxicity at any exposure time and concentration is possible using the model. The use of NLT as a reference point is important since it provides a data point independent of the toxicity data set and limits the data to the range where toxicity occurs.This novel approach, which represents a departure from Haber's rule, can be used to estimate long term toxicity from limited available acute toxicity data for fish exposed to organic biocides.
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View more >A model based on the concept of reduction in life expectancy (RLE model) as a result of long term exposure to toxicant has been developedwhich has normal life expectancy (NLT) as a fixed limiting point for a species.Themodel is based on the equation (LC50 = a ln(LT50) + b) where a and b are constants. It was evaluated by plotting ln LT50 against LC50 with data on organic toxicants obtained from the scientific literature. Linear relationships between LC50 and ln LT50 were obtained and a Calculated NLT was derived from the plots. The Calculated NLT obtained was in good agreement with the Reported NLT obtained from the literature. Estimation of toxicity at any exposure time and concentration is possible using the model. The use of NLT as a reference point is important since it provides a data point independent of the toxicity data set and limits the data to the range where toxicity occurs.This novel approach, which represents a departure from Haber's rule, can be used to estimate long term toxicity from limited available acute toxicity data for fish exposed to organic biocides.
View less >
Journal Title
ISRN Toxicology
Volume
2013
Copyright Statement
© The Author(s) 2013. The attached file is posted here with permission of the copyright owner[s] for your personal use only. No further distribution permitted.For information about this journal please refer to the journal’s website. The online version of this work is licensed under a Creative Commons License, available at http://creativecommons.org/licenses/by-nc-sa/2.1/au/
Subject
Other environmental sciences not elsewhere classified