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dc.contributor.authorBarnes, Emma C
dc.contributor.authorKavanagh, Angela M
dc.contributor.authorRamu, Soumya
dc.contributor.authorBlaskovich, Mark A
dc.contributor.authorCooper, Matthew A
dc.contributor.authorDavis, Rohan A
dc.date.accessioned2017-05-03T12:46:46Z
dc.date.available2017-05-03T12:46:46Z
dc.date.issued2013
dc.date.modified2014-02-26T05:01:01Z
dc.identifier.issn0031-9422
dc.identifier.doi10.1016/j.phytochem.2013.02.021
dc.identifier.urihttp://hdl.handle.net/10072/57012
dc.description.abstractChemical investigations of the aerial parts of the Australian plant Eremophila microtheca resulted in the isolation of three new serrulatane diterpenoids, 3-acetoxy-7,8-dihydroxyserrulat-14-en-19-oic acid (1), 3,7,8-trihydroxyserrulat-14-en-19-oic acid (2), and 3,19-diacetoxy-8-hydroxyserrulat-14-ene (3) as well as the previously reported compounds verbascoside (4) and jaceosidin (5). Acetylation and methylation of the major serrulatane diterpenoid (2) afforded 3,8-diacetoxy-7-hydroxyserrulat-14-en-19-oic acid (6) and 3,7,8-trihydroxyserrulat-14-en-methyl-19-benzoate (7), respectively. The antibacterial activity of 1-7 was assessed against a panel of Gram-positive and Gram-negative bacterial isolates. All the serrulatane compounds exhibited moderate activity against Streptococcus pyogenes (ATCC 12344) with minimum inhibitory concentrations (MICs) ranging from 64-128 姯mL. Serrulatane 1 demonstrated activity against all Gram-positive bacterial strains (MICs 64-128 姯mL) except for Enterococcus faecalis and Enterococcus faecium. This is the first report of natural products from Eremophila microtheca.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent180085 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom162
dc.relation.ispartofpageto169
dc.relation.ispartofjournalPhytochemistry
dc.relation.ispartofvolume93
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiologically active molecules
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical bacteriology
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode340401
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320701
dc.titleAntibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorDavis, Rohan A.


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