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dc.contributor.authorWallwork, B
dc.contributor.authorComan, W
dc.contributor.authorMackay-Sim, A
dc.contributor.authorCervin, A
dc.date.accessioned2017-05-03T11:32:26Z
dc.date.available2017-05-03T11:32:26Z
dc.date.issued2004
dc.date.modified2009-09-21T05:49:11Z
dc.identifier.issn0023-852X
dc.identifier.doi10.1097/00005537-200402000-00019
dc.identifier.urihttp://hdl.handle.net/10072/5705
dc.description.abstractObjectives: Long-term, low-dose macrolide therapy is effective in the treatment of chronic rhinosinusitis. It is believed that macrolide antibiotics produce this benefit through an anti-inflammatory effect. In this study, the effect of clarithromycin treatment on the expression of transforming growth factor (TGF)- and the key pro-inflammatory nuclear transcription factor, NF-B, was examined in vitro and in vivo. Study Design and Methods: In vitro: nasal mucosa was obtained from 10 patients with chronic sinusitis and was cultured for 24 hours in the presence of clarithromycin or control. Cellular expression of TGF- and NF-B was determined by immunohistochemistry. In vivo: 10 patients with chronic rhinosinusitis were treated for 3 months with clarithromycin. Nasal mucosal biopsies were taken pre- and posttreatment. Cellular expression of TGF- and NF-B was again determined by immunohistochemistry. Results: Clarithromycin, when applied to nasal biopsies in vitro, reduced cellular expression of TGF- and NF-B. Nasal biopsies taken before and after clarithromycin treatment showed no differences in cellular expression of NF-B or TGF-. Conclusion: Clarithromycin can reduce cellular expression of TGF- and NF-B when applied in vitro, but its action during clinical therapy is less clear. Clarithromycin is capable of inhibiting pro-inflammatory cytokines in vitro, and reductions of TGF- and NF-B may represent additional mechanisms by which macrolides reduce inflammation in chronic airway disease. Discrepancies between the actions of clarithromycin on nasal biopsies in vitro and after clinical therapy warrant further investigation.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.publisher.placePhiladelphia
dc.publisher.urihttps://onlinelibrary.wiley.com/doi/10.1097/00005537-200402000-00019
dc.relation.ispartofpagefrom286
dc.relation.ispartofpageto290
dc.relation.ispartofissue2
dc.relation.ispartofjournalLaryngoscope
dc.relation.ispartofvolume114
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleEffect of clarithromycin on nuclear factor-KB and transforming growth factor-B in chronic rhinosinusitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2004 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information.
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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